An Active-Site Mutation in the Human Immunodeficiency Virus Type 1 Proteinase(PR) Causes Reduced PR Activity and Loss of PR-Mediated Cytotoxicity without Apparent Effect on Virus Maturation and Infectivity.

KONVALINKA J; LITTERST M A; WELKER R; KOTTLER H; RIPPMANN F; HEUSER A-M; KRAEUSSLICH H-G

Art

J-GLOBAL ID：200902174600530550 Reference number：95A0949648

An Active-Site Mutation in the Human Immunodeficiency Virus Type 1 Proteinase(PR) Causes Reduced PR Activity and Loss of PR-Mediated Cytotoxicity without Apparent Effect on Virus Maturation and Infectivity.

ヒト免疫不全ウイルス1型プロテイナーゼ(PR)での活性部位の変異はウイルスの成熟と感染性に明かな影響を与えることなく,PR活性を低下させ,PR媒介性細胞毒性を消失させる

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Material：
Volume： 69 Issue： 11 Page： 7180-7186 Publication year： Nov. 1995
JST Material Number： B0869A ISSN： 0022-538X CODEN： JOVIAM Document type： Article
Article type：原著論文 Country of issue： United States (USA) Language： ENGLISH (EN)

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Virus physiology in general , Gene manipulation

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