Art

J-GLOBAL ID：200902175596123933   Reference number：97A0603875

Pyrrolidides: synthesis and structure-activity relationship as inhibitors of dipeptidyl peptidase IV.

ピロリジド類 合成およびジペプチジルペプチダーゼIVの阻害薬としての構造活性相関

Author (9)： AUGUSTYNS K J L (Univ. Antwerp(UIA), Antwerp, BEL) ,  LAMBEIR A M (Univ. Antwerp(UIA), Antwerp, BEL) ,  BORLOO M (Univ. Antwerp(UIA), Antwerp, BEL) ,  DE MEESTER I (Univ. Antwerp(UIA), Antwerp, BEL) ,  VEDERNIKOVA I (Univ. Antwerp(UIA), Antwerp, BEL) ,  VANHOOF G (Univ. Antwerp(UIA), Antwerp, BEL) ,  HENDRIKS D (Univ. Antwerp(UIA), Antwerp, BEL) ,  SCHARPE S (Univ. Antwerp(UIA), Antwerp, BEL) ,  HAEMERS A (Univ. Antwerp(UIA), Antwerp, BEL)
Material： European Journal of Medicinal Chemistry  (Eur J Med Chem)
Volume： 32  Issue： 4  Page： 301-309  Publication year： 1997 
JST Material Number： E0845A  ISSN： 0223-5234  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： dipeptidyl peptidase ,...

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JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Pyrroles  (CF07076L)

Substance index (12)： 1-(L-Ile-)Piperidine ,  1-Isoleucylhexahydro-1H-azepine ,  1-Isoleucylazetidine ,  1-Isoleucyl-3-pyrroline ,  1-Isoleucyl-1,2,5,6-tetrahydropyridine ,  N-Cyclopentylisoleucinamide ,  N,N-Dimethylisoleucinamide ,  N,N-Diethylisoleucinamide ,  N-Methyl-N-ethylisoleucinamide ,  N-Methyl-N-propylisoleucinamide ,  1-(3-Cyclohexylalanyl)pyrrolidine ,  1-[(3S)-3-Methylprolyl]pyrrolidine

Terms in the title (3)： ジペプチジルペプチダーゼIV ,  阻害薬 ,  構造活性相関