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J-GLOBAL ID：200902176603026643   Reference number：99A0074903

Establishment and Characterization of a Novel Human Rheumatoid Fibroblast-Like Synoviocyte Line, MH7A, Immortalized with SV40 T Antigen.

SV40 T抗原を用いて不死化した新規ヒトリウマチ線維芽細胞様滑膜細胞MH7Aの樹立と特性化

Author (3)： MIYAZAWA K (Univ. Tokyo, Tokyo) ,  MORI A (National Sagamihara Hospital, Kanagawa) ,  OKUDAIRA H (Univ. Tokyo, Tokyo)
Material： Journal of Biochemistry  (J Biochem)
Volume： 124  Issue： 6  Page： 1153-1162  Publication year： Dec. 1998 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *rheumatoid arthritis ,...

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JST classification (3)： Cytology in general  (EF01000A) ,  Skeletal system  (EJ10030R) ,  Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D)

Substance index (1)： SB-203580

Reference (42)：

• FIRESTEIN, G. S. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 1996, 39, 1781-1790
• LAFYATIS, R. Anchorage-independent growth of synoviocytes from arthritic and normal joints: stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-β and retinoids. J. Clin. Invest. 1989, 83, 1267-1276
• DAYER, J. M. Production of collagenase and prostaglandins by isolated adherent synovial cells. Proc. Natl. Acad. Sci. USA. 1976, 73, 945-949
• CHIN, J. R. Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. J. Biol. Chem. 1985, 260, 12367-12376
• MACNAUL, K. L. Discoordinate expression of stomelysin,collagenase,and tissue inhibitor of metalloproteinase-1 in rheumatoid human synovial fibroblasts: synergistic effects of interleukin-1 and tumor neerosis factor-alpha on stromelysin expresion. J. Bio. Chem. 1990, 265, 17238-17245

Terms in the title (7)： SV40 ,  T抗原 ,  不死化 ,  ヒト ,  リウマチ ,  線維芽細胞様滑膜細胞 ,  特性化