Art

J-GLOBAL ID：200902177789677777   Reference number：01A1013196

Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA-resistant Cell Lines.

エトポシドおよびm-AMSA-耐性細胞株のトポイソメラーゼIIαmRNAにおける突然変異と欠失の発生

Author (5)： MATSUMOTO Y (Kagawa Medical Univ., Kagawa) ,  TAKANO H (Medicine Branch, MD, USA) ,  KUNISHIO K (Kagawa Medical Univ., Kagawa) ,  NAGAO S (Kagawa Medical Univ., Kagawa) ,  FOJO T (Medicine Branch, MD, USA)
Material： Japanese Journal of Cancer Research  (Proceedings. Annual Meeting of the Japanese Cancer Association)
Volume： 92  Issue： 10  Page： 1133-1137  Publication year： Oct. 31, 2001 
JST Material Number： F0633A  ISSN： 0910-5050  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antitumor drug ,...
Semi thesaurus term： DNAトポイソメラーゼIIアルファ ,...

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JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Etoposide ,  Amsacrine

Reference (15)：

• BERGER, J. C. Structure and mechanism of DNA topoisomerase II. Nature. 1996, 379, 225-232
• TAKANO, H. DNA topoisomerase targeting antitumor agents and drug resistance. Anticancer Drugs. 1992, 3, 323-330
• WELLS, N. J. Serine 1524 is a major site of phosphorylation on human topoisomerase IIα protein in vivo and is a substrate for casein kinase II in vitro. J. Biol. Chem. 1994, 270, 29746-29751
• MELTON, D. A. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 1984, 12, 7035-7056
• MICKLEY, L. A. Modulation of the expression of a multidrug resistance gene (mdr-1 /P-glycoprotein) by differentiating agents. J. Biol. Chem. 1989, 264, 18031-18040

Terms in the title (8)： エトポシド ,  m-AMSA ,  耐性 ,  細胞株 ,  トポイソメラーゼIIα ,  mRNA ,  突然変異 ,  欠失