Art

J-GLOBAL ID：200902179145663930   Reference number：01A0528642

Synthesis of Substituted Imidazopyrazines as Ligands for the Human Somatostatin Receptor Subtype 5.

ヒト ソマトスタチン受容体サブタイプ5のリガンドとしての,置換イミダゾピラジン類の合成

Author (7)： CONTOUR-GALCERA M-O (Inst. Henri Beaufour, Les Ulis, FRA) ,  POITOUT L (Inst. Henri Beaufour, Les Ulis, FRA) ,  MOINET C (Inst. Henri Beaufour, Les Ulis, FRA) ,  MORGAN B (Biomeasure Inc., MA, USA) ,  GORDON T (Biomeasure Inc., MA, USA) ,  ROUBERT P (Inst. Henri Beaufour, Les Ulis, FRA) ,  THURIEAU C (Inst. Henri Beaufour, Les Ulis, FRA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 11  Issue： 5  Page： 741-745  Publication year： Mar. 12, 2001 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *somatostatin receptor ,...
Semi thesaurus term： insulin

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JST classification (2)： Synthesis of drugs  (GV01030F) ,  Pyrazines  (CF07104N)

Substance index (28)： MK-678 ,  Sandostatin ,  lanreotide acetate ,  L-054264 ,  L-054522 ,  NNC-26-9100 ,  Boc-L-Trp-OH ,  Boc-Phenylalanine ,  N²-(tert-Butoxycarbonyl)-N⁶-(benzyloxycarbonyl)lysine ,  Boc-lysine ,  N-(2-Aminoethyl)-2,2-dimethyl-3-oxo-4-bromobutanamide ,  α-Bromoacetophenone ,  N-[2-(1H-Indole-3-yl)ethyl]-2,2-dimethyl-3-oxo-4-bromobutanamide ,  N-Cyclohexyl-2,2-dimethyl-3-oxo-4-bromobutanamide ,  3-(Bromoacetyl)benzo[b]thiophene ,  α-Bromo-3'-nitroacetophenone ,  1-Bromo-3-phenyl-2-propanone ,  1-(1H-Indole-3-yl)-3-bromo-2-propanone ,  2-[1-Methyl-1-(2-aminoethylcarbamoyl)ethyl]-6-benzyl-8-(1H-indole-3-ylmethyl)-5,8-dihydroimidazo[1,2-a]pyrazine ,  2,6-Diphenyl-8-benzyl-5,8-dihydroimidazo[1,2-a]pyrazine ,  2,6-Diphenyl-8-[4-(benzyloxycarbonylamino)butyl]-5,8-dihydroimidazo[1,2-a]pyrazine ,  2-[1-Methyl-1-[2-(1H-indole-3-yl)ethylcarbamoyl]ethyl]-6-(benzo[b]thiophene-3-yl)-8-(4-aminobutyl)-5,8-dihydroimidazo[1,2-a]pyrazine ,  2-Phenyl-6-(3-nitrophenyl)-8-(4-aminobutyl)-5,8-dihydroimidazo[1,2-a]pyrazine ,  2-[1-Methyl-1-[2-(1H-indole-3-yl)ethylcarbamoyl]ethyl]-6-phenethyl-8-(4-aminobutyl)-5,8-dihydroimidazo[1,2-a]pyrazine ,  2-[1-Methyl-1-(butylcarbamoyl)ethyl]-6-(benzo[b]thiophene-3-yl)-8-(4-aminobutyl)-5,8-dihydroimidazo[1,2-a]pyrazine ,  2-[1-Methyl-1-(cyclohexylcarbamoyl)ethyl]-6-(benzo[b]thiophene-3-yl)-8-(4-aminobutyl)-5,8-dihydroimidazo[1,2-a]pyrazine ,  2-Phenyl-6-(1H-indole-3-ylmethyl)-8-(4-aminobutyl)-5,8-dihydroimidazo[1,2-a]pyrazine ,  2-Phenyl-6-(benzo[b]thiophene-3-yl)-8-(4-aminobutyl)-5,8-dihydroimidazo[1,2-a]pyrazine

Terms in the title (5)： ヒト ,  ソマトスタチン受容体 ,  サブタイプ ,  リガンド ,  置換