Art

J-GLOBAL ID：200902180357881358   Reference number：02A0460368

Stereoselective Total Synthesis of Epothilones by the Metathesis Approach Involving C9-C10 Bond Formation.

C9-C10結合生成を含むメタセシス法によるエポチロン類の立体選択的全合成

Author (2)： SUN J (Scripps Res. Inst., California, USA) ,  SINHA S C (Scripps Res. Inst., California, USA)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 41  Issue： 8  Page： 1381-1383  Publication year： Apr. 15, 2002 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *macrolide antibiotics ,...
Semi thesaurus term： metathesis ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=02A0460368&from=J-GLOBAL&jstjournalNo=H0127B") }}

JST classification (2)： Eight or more-membered heterocyclic compounds  (CF07120T) ,  Synthesis of antibiotics  (GX04000Z)

Substance index (18)： Epothilone A ,  Epothilone B ,  Epothilone C ,  Epothilone D ,  Epothilone E ,  Epothilone F ,  1,3-Dimesitylimidazolidine ,  Tricyclohexylphosphine ,  Toluene ,  (4S)-4-Hydroxy-5-methyl-6-(2-methyl-4-thiazolyl)-5-hexene-2-one ,  (3S,6R,7S,8S)-3,7-Bis(tert-butyldimethylsiloxy)-4,4,6,8-tetramethyl-5-oxo-9-decenoic acid ,  (1E,3S,5S,6R)-1-(2-Methyl-4-thiazolyl)-2,6-dimethyl-5,6-epoxy-1,8-nonadiene-3-ol ,  (3S,6R,7S,8S)-3,7-Bis(tert-butyldimethylsilyloxy)-4,4,6,8-tetramethyl-5-oxo-9-decenoic acid (1S,3S,4R)-1-[(E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-3,4-epoxy-4-methyl-6-heptene-1-yl ester ,  (1S,3S,7S,10R,11S,12S,16R)-3-[(E)-1-Methyl-2-(2-methyl-4-thiazolyl)ethenyl]-7,11-bis(tert-butyldimethylsilyloxy)-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-13-ene-5,9-dione ,  (3S,6R,7S,8S)-3,7-Bis(tert-butyldimethylsilyloxy)-4,4,6,8-tetramethyl-5-oxo-9-decenoic acid (1S)-1-[(E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-3-methyl-3,6-heptadienyl ester ,  (3S,6R,7S,8S)-3,7-Bis(tert-butyldimethylsilyloxy)-4,4,6,8-tetramethyl-5-oxo-9-decenoic acid (1S,3Z)-1-[(E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4-(methoxymethoxymethyl)-3,6-heptadienyl ester ,  (4S,7R,8S,9S,10E,13Z,16S)-4,8-Bis(tert-butyldimethylsilyloxy)-5,5,7,9,14-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-1-oxacyclohexadeca-10,13-diene-2,6-dione ,  (4S,7R,8S,9S,10E,13Z,16S)-4,8-Bis(tert-butyldimethylsilyloxy)-5,5,7,9-tetramethyl-13-(methoxymethoxymethyl)-16-[(E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-1-oxacyclohexadeca-10,13-diene-2,6-dione

Terms in the title (5)： C9 ,  メタセシス ,  エポチロン類 ,  立体 ,  全合成