Art

J-GLOBAL ID：200902180573845145   Reference number：95A0252917

Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)-Linked Bis-Tetraazamacrocycles That Inhibit HIV Replication. Effects of Macrocyclic Ring Size and Substituents on the Aromatic Linker.

HIV複製を阻害するフェニレンビス(メチレン)結合ビステトラアザ大員環の合成と構造活性相関 大員環の環サイズと芳香族リンカー上の置換基の影響

Author (9)： BRIDGER G J (Johnson Matthey Technology Centre, Reading, GBR) ,  SKERLJ R T (Johnson Matthey Pharmaceutical Research, Pennsylvania) ,  PADMANABHAN S (Johnson Matthey Pharmaceutical Research, Pennsylvania) ,  MARTELLUCCI S A (Johnson Matthey Pharmaceutical Research, Pennsylvania) ,  ABRAMS M J (Johnson Matthey Pharmaceutical Research, Pennsylvania) ,  YAMAMOTO N (Katholieke Univ. Leuven, Leuven, BEL) ,  DE VREESE K (Katholieke Univ. Leuven, Leuven, BEL) ,  PAUWELS R (Katholieke Univ. Leuven, Leuven, BEL) ,  DE CLERCQ E (Katholieke Univ. Leuven, Leuven, BEL)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 38  Issue： 2  Page： 366-378  Publication year： Jan. 20, 1995 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： macrocyclic compound ,...
Semi thesaurus term： tetraazacyclododecane ,...

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JST classification (1)： Basic research of antiviral drugs  (GW17040O)

Substance index (22)： JM-2763 ,  AMD-3100 ,  1,1′-(1,4-Phenylenebismethylene)bis(1,4,7,10-tetraazacyclodecane) ,  4,4′-p-Xylylenebis(1,4,7,10-tetraazacyclotridecane) ,  AMD-6038 ,  Mozobil ,  1,1′-(1,4-Phenylenebismethylene)bis(1,5,8,12-tetraazacyclopentadecane) ,  1,1′-(1,4-Phenylenebismethylene)bis(1,5,9,13-tetraazacyclohexadecane) ,  1,1′-(2,5-Dimethyl-p-phenylenebismethylene)bis(1,4,8,11-tetraazacyclotetradecane) ,  AMD-3166 ,  1,1′-[(2-Bromo-1,4-phenylene)bismethylene]bis(1,4,8,11-tetraazacyclotetradecane) ,  1,1′-(2-Nitro-p-phenylenebismethylene)bis(1,4,8,11-tetraazacyclotetradecane) ,  AMD-3207 ,  AMD-3070 ,  AMD-3196 ,  AMD-3203 ,  1,1′-(2-Bromo-m-phenylenebismethylene)bis(1,4,8,11-tetraazacyclotetradecane) ,  1,1′-(5-Bromo-m-phenylenebismethylene)bis(1,4,8,11-tetraazacyclotetradecane) ,  AMD-3068 ,  1,1′-(Tetrachloro-m-phenylenebismethylene)bis(1,4,8,11-tetraazacyclotetradecane) ,  AMD-3390 ,  1,1′-[(p-Phenylene)bistrimethylene]bis(1,4,8,11-tetraazacyclotetradecane)

Terms in the title (10)： HIV ,  複製 ,  阻害 ,  メチレン ,  環 ,  構造活性相関 ,  サイズ ,  芳香族 ,  リンカー ,  置換基