Chimeric snRNA molecules carrying antisense sequences against the splice junctions of exon 51 of the dystrophin pre-mRNA induce exon skipping and restoration of a dystrophin synthesis in Δ48-50 DMD cells.

DE ANGELIS F G; STHANDIER O; BERARDUCCI B; TOSO S; GALLUZZI G; RICCI E; COSSU G; BOZZONI I

Art

J-GLOBAL ID：200902181943409478 Reference number：02A0642280

Chimeric snRNA molecules carrying antisense sequences against the splice junctions of exon 51 of the dystrophin pre-mRNA induce exon skipping and restoration of a dystrophin synthesis in Δ48-50 DMD cells.

ジストロフィンのプレmRNAのエキソン51のスプライスジャンクションに対するアンチセンス配列をもつキメラsnRNA分子は,Δ48-50DMD細胞におけるジストロフィン合成のエキソンスキッピングおよび修復を誘導する

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Material：
Volume： 99 Issue： 14 Page： 9456-9461 Publication year： Jul. 09, 2002
JST Material Number： D0387A ISSN： 0027-8424 Document type： Article
Article type：原著論文 Country of issue： United States (USA) Language： ENGLISH (EN)

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Gene manipulation , Basic medicine on musculoskeletal system

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