Art

J-GLOBAL ID：200902181979667678   Reference number：98A0143426

Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists.

グリシン/NMDA受容体きっ抗薬のin vivo活性と脳への透過における血しょう蛋白結合の効果

Author (9)： ROWLEY M (Neurosci. Res. Centre, Essex, GBR) ,  KULAGOWSKI J J (Neurosci. Res. Centre, Essex, GBR) ,  WATT A P (Neurosci. Res. Centre, Essex, GBR) ,  RATHBONE D (Neurosci. Res. Centre, Essex, GBR) ,  STEVENSON G I (Neurosci. Res. Centre, Essex, GBR) ,  CARLING R W (Neurosci. Res. Centre, Essex, GBR) ,  BAKER R (Neurosci. Res. Centre, Essex, GBR) ,  MARSHALL G R (Neurosci. Res. Centre, Essex, GBR) ,  LEESON P D (Neurosci. Res. Centre, Essex, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 40  Issue： 25  Page： 4053-4068  Publication year： Dec. 05, 1997 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： anticonvulsant ,...
Semi thesaurus term： hydroquinolines ,...

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JST classification (1)： Basic research of antiepileptics and anticonvulsants  (GW03060D)

Substance index (26)： 2-Oxo-4-hydroxy-7-chloro-1,2-dihydro-3-quinolinecarboxylic acid ethyl ester ,  L-695902 ,  2-Oxo-4-hydroxy-7-nitro-1,2-dihydroquinoline-3-carboxylic acid ethyl ester ,  [(2-Oxo-4-hydroxy-7-chloro-1,2-dihydroquinolin)-3-yl](2-thienyl) ketone ,  1-[(2-Oxo-4-hydroxy-7-chloro-1,2-dihydroquinolin)-3-yl]-2-phenylethanone ,  [(2-Oxo-4-hydroxy-7-chloro-1,2-dihydroquinolin)-3-yl](1-benzothiophen-3-yl) ketone ,  3-p-Tolyl-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-(4-Fluorophenyl)-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-(3-Methoxyphenyl)-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-(3-Phenoxyphenyl)-4-hydroxy-5-ethyl-7-chloro-2(1H)-quinolone ,  3-(3-Benzylphenyl)-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-(5-Methyl-2-furyl)-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-[3-(2-Methylphenoxy)phenyl]-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-[3-(Benzylamino)phenyl]-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-[3-(2-Methoxybenzyl)phenyl]-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-[3-[4-(Methylaminomethyl)benzyl]phenyl]-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-[3-[4-(2-Morpholinoethyl)benzyl]phenyl]-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-[(2-Oxo-4-hydroxy-7-chloro-1,2-dihydroquinolin)-3-yl]benzoic acid ,  3-(3-Methyl-1H-indol-1-yl)-4-hydroxy-7-chloro-2(1H)-quinolone ,  3-(3-Phenoxyphenyl)-4-hydroxy-5-propylidene-1H-pyrrol-2(5H)-one ,  3-[3-(2-Methylallyloxy)phenyl]-4-hydroxy-5-propylidene-1H-pyrrol-2(5H)-one ,  L-698544 ,  3-(3-Oxo-3-anilino-1-propenyl)-4,6-dichloro-1H-indole-2-carboxylic acid ,  5,7-Dinitroquinoxaline-2,3(1H,4H)-dione ,  ACEA-1021 ,  rac-(5R^*)-N-フェニル-2,3-ジオキソ-9-ブロモ-2,3,6,7-テトラヒドロ-1H,5H-ピリド[1,2,3-de]キノキサリン-5-アセトアミド

Terms in the title (6)： グリシン ,  NMDA受容体きっ抗薬 ,  活性 ,  脳 ,  透過 ,  血しょう蛋白