Art

J-GLOBAL ID：200902183231445969   Reference number：00A0868060

Total Synthesis of Reveromycin A.

レベロマイシンAの全合成

Author (4)： SHIMIZU T (RIKEN (The Inst. Physical and Chemical Res.), Saitama, JPN) ,  MASUDA T (RIKEN (The Inst. Physical and Chemical Res.), Saitama, JPN) ,  HIRAMOTO K (RIKEN (The Inst. Physical and Chemical Res.), Saitama, JPN) ,  NAKATA T (RIKEN (The Inst. Physical and Chemical Res.), Saitama, JPN)
Material： Organic Letters  (Org Lett)
Volume： 2  Issue： 14  Page： 2153-2156  Publication year： Jul. 13, 2000 
JST Material Number： W1171A  ISSN： 1523-7060  CODEN： ORLEF7  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *total synthesis ,...
Semi thesaurus term： polyketide

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JST classification (2)： Pyranes  (CF07092R) ,  Synthesis of antibiotics  (GX04000Z)

Substance index (10)： 5-Hydroxy-4,8-dimethyl-10-[9-butyl-3-methyl-8-(4-carboxy-3-methyl-1,3-butadienyl)-9-(4-hydroxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecan-2-yl]-2,6,8-decatrienoic acid ,  (3S,4R)-3-Methyl-4-(triethylsilyloxy)-6-(4-methoxybenzyloxy)-1-hexyne ,  (2S,3R,6S,8R,9S)-2-(tert-Butyldiphenylsiloxymethyl)-3-butyl-8-[2-(4-methoxybenzyloxy)ethyl]-9-methyl-1,7-dioxaspiro[5.5]undecane-3-ol ,  (2E,4E)-3-Methyl-5-[(2S,6S)-3α-[(4-allyloxy-1,4-dioxobutyl)oxy]-3-butyl-8α-(2-hydroxyethyl)-9β-methyl-1,7-dioxaspiro[5.5]undecane-2β-yl]-2,4-pentadienoic acid allyl ester ,  (2E,4E)-3-Methyl-5-[(2S,6S)-3α-[(4-allyloxy-1,4-dioxobutyl)oxy]-3-butyl-8α-[(E)-3-methyl-4-oxo-2-butenyl]-9β-methyl-1,7-dioxaspiro[5.5]undecane-2β-yl]-2,4-pentadienoic acid allyl ester ,  (2E,4E)-3-Methyl-5-[(2S,6S)-3α-[(4-allyloxy-1,4-dioxobutyl)oxy]-3-butyl-8α-[(E)-3-methyl-4-hydroxy-2-butenyl]-9β-methyl-1,7-dioxaspiro[5.5]undecane-2β-yl]-2,4-pentadienoic acid allyl ester ,  (2E,4E)-3-Methyl-5-[(2S,6S)-3α-[(4-allyloxy-1,4-dioxobutyl)oxy]-3-butyl-8α-[(E)-3-methyl-4-(benzothiazole-2-ylsulfonyl)-2-butenyl]-9β-methyl-1,7-dioxaspiro[5.5]undecane-2β-yl]-2,4-pentadienoic acid allyl ester ,  (2E,4E)-3-Methyl-5-[(2S,6S)-3α-[(4-allyloxy-1,4-dioxobutyl)oxy]-3-butyl-8α-[(2E,4E,6S,7S)-3,7-dimethyl-6-[(tert-butyldimethylsilyl)oxy]-8-[(triethylsilyl)oxy]-2,4-octadienyl]-9β-methyl-1,7-dioxaspiro[5.5]undecane-2β-yl]-2,4-pentadienoic acid allyl ester ,  (2E,4E)-3-Methyl-5-[(2S,6S)-3α-[(4-allyloxy-1,4-dioxobutyl)oxy]-3-butyl-8α-[(2E,4E,6S,7R)-3,7-dimethyl-6-[(tert-butyldimethylsilyl)oxy]-8-oxo-2,4-octadienyl]-9β-methyl-1,7-dioxaspiro[5.5]undecane-2β-yl]-2,4-pentadienoic acid allyl ester ,  (4S,5S,6E,8E)-4,8-Dimethyl-5-[(tert-butyldimethylsilyl)oxy]-10-[(2R,6S)-3β-methyl-8β-[(1E,3E)-3-methyl-5-allyloxy-5-oxo-1,3-pentadienyl]-9α-[(4-allyloxy-1,4-dioxobutyl)oxy]-9-butyl-1,7-dioxaspiro[5.5]undecane-2α-yl]-2,6,8-decatrienoic acid allyl ester

Terms in the title (2)： レベロマイシンA ,  全合成