Art

J-GLOBAL ID：200902183494404000   Reference number：00A0042288

Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation.

ヒストンデアセチラーゼの阻害と終末細胞分化の誘発剤としてのトリコスタチンAのアミド類似体

Author (6)： JUNG M (Westfaelische Wilhelms-Univ. Muenster, Muenster, DEU) ,  BROSCH G (Univ. Innsbruck, Innsbruck, AUT) ,  KOELLE D (Univ. Innsbruck, Innsbruck, AUT) ,  SCHERF H (German Cancer Res. Center, Heidelberg, DEU) ,  GERHAEUSER C (German Cancer Res. Center, Heidelberg, DEU) ,  LOIDL P (Univ. Innsbruck, Innsbruck, AUT)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 42  Issue： 22  Page： 4669-4679  Publication year： Nov. 04, 1999 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： cell differentiation ,...

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (26)： Trichostatin A ,  (6R)-N-Hydroxy-4,6-dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienamide ,  MD-85 ,  6-[[4-(Dimethylamino)benzoyl]amino]hexanoic acid ,  4-[[4-(Dimethylamino)benzoyl]amino]butanehydroxamic acid ,  4-[[4-(Dimethylamino)benzoyl]amino]butanoic acid ,  5-[4-(Dimethylamino)benzoylamino]pentanehydroxamic acid ,  5-[[4-(Dimethylamino)benzoyl]amino]pentanoic acid ,  M-344 ,  7-[[4-(Dimethylamino)benzoyl]amino]heptanoic acid ,  8-[4-(Dimethylamino)benzoylamino]octanehydroxamic acid ,  8-[[4-(Dimethylamino)benzoyl]amino]octanoic acid ,  4-[[4-(Dimethylamino)benzoyl]amino]phenylacetohydroxamic acid ,  4-[[4-(Dimethylamino)benzoyl]amino]phenylacetic acid ,  4-[[[4-(Dimethylamino)benzoyl]amino]methyl]benzohydroxamic acid ,  4-[[[4-(Dimethylamino)benzoyl]amino]methyl]benzoic acid ,  6-[(4-Methoxybenzoyl)amino]hexanehydroxamic acid ,  6-[(4-Methoxybenzoyl)amino]hexanoic acid ,  M-354 ,  6-Benzoylaminocaproic acid ,  6-(4-Chlorobenzoylamino)hexanehydroxamic acid ,  6-[(4-Chlorobenzoyl)amino]hexanoic acid ,  M-353 ,  6-[(4-Nitrobenzoyl)amino]hexanoic acid ,  6-(4-Phenylbenzoylamino)hexanehydroxamic acid ,  6-[(1,1′-Biphenyl-4-ylcarbonyl)amino]hexanoic acid

Terms in the title (7)： ヒストンデアセチラーゼ ,  阻害 ,  細胞分化 ,  誘発 ,  トリコスタチンA ,  アミド ,  類似体