Art

J-GLOBAL ID：200902185095886886   Reference number：02A0696105

Novel Indolo[2,1-b]quinazoline Analogues as Cytostatic Agents: Synthesis, Biological Evaluation and Structure-Activity Relationship.

細胞増殖抑制薬としての新規インドロ[2,1-b]キナゾリン類似体 合成,生物学的評価,および構造活性相関

Author (9)： SHARMA V M (Dr. Reddy’s Res. Foundation, Hyderabad, IND) ,  PRASANNA P (Dr. Reddy’s Res. Foundation, Hyderabad, IND) ,  SESHU K V A (Dr. Reddy’s Res. Foundation, Hyderabad, IND) ,  RENUKA B (Dr. Reddy’s Res. Foundation, Hyderabad, IND) ,  RAO C V L (Dr. Reddy’s Res. Foundation, Hyderabad, IND) ,  KUMAR G S (Dr. Reddy’s Res. Foundation, Hyderabad, IND) ,  NARASIMHULU C P (Dr. Reddy’s Res. Foundation, Hyderabad, IND) ,  BABU P A (Dr. Reddy’s Res. Foundation, Hyderabad, IND) ,  RAJAGOPALAN R (Dr. Reddy’s Res. Foundation, Hyderabad, IND)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 12  Issue： 17  Page： 2303-2307  Publication year： Sep. 02, 2002 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： B16 cell

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JST classification (2)： Pyrimidines  (CF07103W) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (34)： Tryptanthrine ,  2-Bromoindolo[2,1-b]quinazoline-6,12-dione ,  2-Nitroindolo[2,1-b]quinazoline-6,12-dione ,  2,3-Dimethoxy-6,12-dihydroindolo[2,1-b]quinazoline-6,12-dione ,  2-Aminotryptanthrine ,  8-Bromotryptanthrine ,  8,9-(Epoxymethanoxy)-6,12-dihydroindolo[2,1-b]quinazoline-6,12-dione ,  8-Methoxyindolo[2,1-b]quinazoline-6,12-dione ,  8-Methyltryptanthrine ,  8-Chlorotryptanthrine ,  8-(Acetylamino)-6,12-dihydroindolo[2,1-b]quinazoline-6,12-dione ,  8-(Butyrylamino)-6,12-dihydroindolo[2,1-b]quinazoline-6,12-dione ,  8-(Propionylamino)-6,12-dihydroindolo[2,1-b]quinazoline-6,12-dione ,  8-(Chloroacetylamino)-6,12-dihydroindolo[2,1-b]quinazoline-6,12-dione ,  8-(4-Methylpiperazinoacetylamino)-6,12-dihydroindolo[2,1-b]quinazoline-6,12-dione ,  8-(Methylsulfonylamino)-6,12-dihydroindolo[2,1-b]quinazoline-6,12-dione ,  6-Hydroxy-6-methyl-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-Hydroxy-6-vinyl-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-Hydroxy-6-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-Hydroxy-6-(2-phenoxyethoxy)-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-(Hydroxyimino)-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-(2-Hydroxyethoxyimino)-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-(2-Oxo-2-methoxyethoxyimino)-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-[2-Oxo-2-(2-pyridinylamino)ethoxyimino]-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-(3-Phenylacryloyloxyimino)-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-[3-(Dimethylamino)propoxyimino]-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-[2-(Dimethylamino)ethoxyimino]-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-(2-Pyrrolizinoethoxyimino)-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-(3-Pyrrolizinopropoxyimino)-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-[2-(Dimethylamino)ethoxyimino]-8-nitro-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-[3-(Dimethylamino)propoxyimino]-8-nitro-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-(2-Hydroxyethoxyimino)-8-nitro-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-[2-(Dimethylamino)ethoxyimino]-8-bromo-6,12-dihydroindolo[2,1-b]quinazoline-12-one ,  6-(2-Piperidinoethoxyimino)-8-bromo-6,12-dihydroindolo[2,1-b]quinazoline-12-one

Terms in the title (6)： 細胞増殖抑制 ,  インド ,  キナゾリン ,  類似体 ,  生物学的評価 ,  構造活性相関