Art

J-GLOBAL ID：200902186502543138   Reference number：01A0579598

Synthesis and Antimalarial Activity of Febrifugine Derivatives.

フェブリフギン誘導体の合成及び抗マラリア活性

Author (8)： TAKEUCHI Y (Okayama Univ., Okayama, JPN) ,  KOIKE M (Okayama Univ., Okayama, JPN) ,  AZUMA K (Okayama Univ., Okayama, JPN) ,  NISHIOKA H (Okayama Univ., Okayama, JPN) ,  ABE H (Okayama Univ., Okayama, JPN) ,  KIM H-S (Okayama Univ., Okayama, JPN) ,  WATAYA Y (Okayama Univ., Okayama, JPN) ,  HARAYAMA T (Okayama Univ., Okayama, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 49  Issue： 6  Page： 721-725  Publication year： Jun. 01, 2001 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...
Semi thesaurus term： bridged compound ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=01A0579598&from=J-GLOBAL&jstjournalNo=G0504A") }}

JST classification (2)： Pyrimidines  (CF07103W) ,  Synthesis of drugs  (GV01030F)

Substance index (30)： Febrifugine ,  Isofebrifugine ,  3-[2-Oxo-3-[(3R)-3α-hydroxy-4β-piperidinyl]propyl]-3,4-dihydroquinazoline-4-one ,  3-[[(3aβ,7aβ)-2-Hydroxyoctahydrofuro[2,3-c]pyridine-2-yl]methyl]-3,4-dihydroquinazoline-4-one ,  1-Benzyl-3-hydroxypyridinium ,  3-(Allyloxy)-1,2,5,6-tetrahydropyridine 1-carboxylic acid benzyl ester ,  3-Oxo-4-allyl-1-piperidinecarboxylic acid benzyl ester ,  (3R)-3α-Hydroxy-4β-allyl-1-piperidinecarboxylic acid benzyl ester ,  (3R)-3α-Hydroxy-4α-allyl-1-piperidinecarboxylic acid benzyl ester ,  (3aα,7aβ)-2-(Bromomethyl)octahydrofuro[2,3-c]pyridine-6-carboxylic acid benzyl ester ,  (3aβ,7aβ)-2-(Bromomethyl)octahydrofuro[2,3-c]pyridine-6-carboxylic acid benzyl ester ,  (3aα,7aβ)-2-Methoxy-2-(bromomethyl)octahydrofuro[2,3-c]pyridine-6-carboxylic acid benzyl ester ,  Quinazolin-4(3H)-one ,  (3R)-3α-Hydroxy-4β-[3-(4-oxo-3,4-dihydroquinazoline-3-yl)-2-oxopropyl]-1-piperidinecarboxylic acid benzyl ester ,  3-[2-Oxo-3-[(3R)-1-benzyl-3α-hydroxy-4β-piperidinyl]propyl]-3,4-dihydroquinazoline-4-one ,  1-(Benzyloxycarbonyl)-2-allylpiperidine-3-one ,  (2R)-2α-Allyl-3β-hydroxy-1-piperidinecarboxylic acid benzyl ester ,  (2S)-1-(Benzyloxycarbonyl)-2β-allylpiperidine-3β-ol ,  2-Allyl-3-oxo-1-piperidinecarboxylic acid methyl ester ,  3-Oxo-4-allyl-1-piperidinecarboxylic acid methyl ester ,  (+-)-Febrifugine ,  dl-Isofebrifugine ,  (3R)-3α-(Benzoyloxy)-4β-allyl-1-piperidinecarboxylic acid benzyl ester ,  Benzoic acid (3R)-4β-propyl-3α-piperidinyl ester ,  (3R)-3α-(Benzoyloxy)-4α-allyl-1-piperidinecarboxylic acid benzyl ester ,  Benzoic acid (3R)-4α-propyl-3α-piperidinyl ester ,  Quinine ,  Chloroquine ,  Pyrimethamin ,  Artemisinin

Reference (20)：

• 1) Koepfli J.B., Mead J.F., Brockman J.A., Jr., J. Am. Chem. Soc., 69, 1837 (1947);
•  Idem, ibid., 71, 1048-1054 (1949);
•  Ablondi F., Gordon S., Morton J., II, Williams J.H., J. Org. Chem., 17, 14-18 (1952);
•  Hutchings B.L., Gordon S., Ablondi F., Wolf C.F., Williams J.H., ibid., 17, 19-34 (1952).
• 2) Kobayashi S., Ueno M., Suzuki R., Ishitani H., Tetrahedron Lett., 40, 2175-2178 (1999);

Terms in the title (3)： フェブリフギン ,  誘導体 ,  抗マラリア活性