Art

J-GLOBAL ID：200902188660083570   Reference number：01A0781601

Discovery of 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an Orally Active, Non-Nucleoside Adenosine Kinase Inhibitor.

経口活性な非ヌクレオシド系アデノシンキナーゼ阻害薬,4-アミノ-5-(3-ブロモフェニル)-7-(6-モルホリノピリジン-3-イル)ピリド[2,3-d]ピリミジンの発見

Author (9)： LEE C-H (Abbott Lab., Illinois) ,  JIANG M (Abbott Lab., Illinois) ,  COWART M (Abbott Lab., Illinois) ,  GFESSER G (Abbott Lab., Illinois) ,  PERNER R (Abbott Lab., Illinois) ,  KIM K H (Abbott Lab., Illinois) ,  JARVIS M F (Abbott Lab., Illinois) ,  KOWALUK E A (Abbott Lab., Illinois) ,  BHAGWAT S S (Abbott Lab., Illinois)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 44  Issue： 13  Page： 2133-2138  Publication year： Jun. 21, 2001 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...

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JST classification (2)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Pyrimidines  (CF07103W)

Substance index (21)： 5'-Amino-5'-deoxyadenosine ,  5-Iodo-5'-deoxytubercidin ,  Clitocine ,  7-(5-Deoxy-β-D-ribofuranosyl)-N-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine ,  7-[4-(Dimethylamino)phenyl]-4-pteridinamine ,  7-Phenylpteridine-4-amine ,  7-(4-Aminophenyl)pteridine-4-amine ,  7-(4-Nitrophenyl)pteridine-4-amine ,  7-(4-Methoxyphenyl)pteridine-4-amine ,  7-(4-Morpholinophenyl)pteridine-4-amine ,  6-Phenyl-7-[4-(dimethylamino)phenyl]pteridine-4-amine ,  7-[4-(Dimethylamino)phenyl]pyrido[2,3-d]pyrimidine-4-amine ,  6-(4-Methylphenyl)-7-[4-(dimethylamino)phenyl]pyrido[2,3-d]pyrimidine-4-amine ,  6-(4-tert-Butylphenyl)-7-[4-(dimethylamino)phenyl]pyrido[2,3-d]pyrimidine-4-amine ,  6-(4-Methoxyphenyl)-7-[4-(dimethylamino)phenyl]pyrido[2,3-d]pyrimidine-4-amine ,  6-[3-(Methoxycarbonyl)phenyl]-7-[4-(dimethylamino)phenyl]pyrido[2,3-d]pyrimidine-4-amine ,  5-Phenyl-7-[4-(dimethylamino)phenyl]pyrido[2,3-d]pyrimidine-4-amine ,  5-Cyclohexyl-7-[4-(dimethylamino)phenyl]pyrido[2,3-d]pyrimidine-4-amine ,  5-(3-Bromophenyl)-7-[4-(dimethylamino)phenyl]pyrido[2,3-d]pyrimidine-4-amine ,  5-(3-Bromophenyl)-7-[6-(dimethylamino)-3-pyridyl]pyrido[2,3-d]pyrimidine-4-amine ,  ABT-702

Terms in the title (6)： 活性 ,  ヌクレオシド ,  アデノシンキナーゼ ,  阻害薬 ,  ピリミジン ,  発見