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J-GLOBAL ID：200902190571491791   Reference number：03A0037012

Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols.

コスツノリドはヒト白血病U937細胞の細胞内チオールを欠乏させることによってアポプトシスを誘導する

Author (9)： CHOI J-H (Kyung-Hee Univ., Seoul, KOR) ,  HA J (Kyung-Hee Univ., Seoul, KOR) ,  PARK J-H (Kyung-Hee Univ., Seoul, KOR) ,  LEE J Y (KIST, Seoul, KOR) ,  LEE Y S (KIST, Seoul, KOR) ,  PARK H-J (Sangji Univ., Wonju, KOR) ,  CHOI J-W (Kyung-Sung Univ., Pusan, KOR) ,  MASUDA Y (Showa Univ., Tokyo) ,  LEE K-T (Kyung-Hee Univ., Seoul, KOR)
Material： Japanese Journal of Cancer Research  (Proceedings. Annual Meeting of the Japanese Cancer Association)
Volume： 93  Issue： 12  Page： 1327-1333  Publication year： Dec. 31, 2002 
JST Material Number： F0633A  ISSN： 0910-5050  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Magnolia ,...
Semi thesaurus term： Magnolia sieboldii ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (5)： Costunolide ,  Glutathione ,  Acetylcysteine ,  Dithiothreitol ,  2-Mercaptoethanol

Reference (26)：

• DIRSCH, V. M. Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis. Planta Med. 2001, 67, 557-559
• DIRSCH, V. M. triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2. Cancer Res. 2001, 61, 5817-5823
• MORI, H. Chemopreventive effect of costunolide, a constituent of oriental medicine, on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett. 1994, 83, 171-175
• KINLOCH, R. A. The pharmacology of apoptosis. Trends Pharmacol. Sci. 1999, 20, 35-42
• HANNUN, Y. A. Apoptosis and the dilemma of cancer chemotherapy. Blood. 1997, 89, 1845-1853

Terms in the title (8)： コスツノリド ,  ヒト ,  白血病 ,  U937細胞 ,  チオール ,  欠乏 ,  アポプトシス ,  誘導