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J-GLOBAL ID：200902191888661540   Reference number：04A0433073

Hepatocyte Growth Factor (HGF) Prevent Progression of Renal Interstitial Fibrosis via Its Counteraction Against Transforming Growth Factor-beta (TGF-β) in 5/6 Nephrectomized Mice

Transforming Growth Factor-beta(TGF-β)とのきっ抗作用によるHepatocyte Growth Factor(HGF)の抗腎線維化作用の検討

Author (1)： INOUE TSUTOMU (埼玉医大 医 腎臓内科)
Material： 埼玉医科大学雑誌(Web)  (Journal of Saitama Medical University (Web))
Volume： 29  Issue： 1  Page： 13-26 (WEB ONLY)  Publication year： Jan. 2002 
JST Material Number： U0005A  ISSN： 1347-1031  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： transgenic mouse ,...
Semi thesaurus term： 腎線維症 ,...

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JST classification (2)： Cytokines  (EB08090G) ,  Basic medicine on urogenital system  (GM01020T)

Reference (49)：

• 1) Okada H, Strutz F, Danoff TM, Neilson EG. Possible pathogenesis of renal fibrosis. Kidney Int Suppl 1996; 54: S37-8.
• 2) Risdon RA, Sloper JC, De Wardener HE. Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 1968; 2: 363-6.
• 3) Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331: 1286-92.
• 4) Bradham DM, Igarashi A, Potter RL, Grotendorst GR. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 1991; 114: 1285-94.
• 5) Gupta S, Clarkson MR, Duggan J, Brady HR. Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int 2000; 58: 1389-99.

Terms in the title (3)： きっ抗作用 ,  HGF ,  腎線維化