Art

J-GLOBAL ID：200902192200326170   Reference number：94A0006526

3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically Active Anticonvulsants Acting by Antagonism at the Glycine Site of the N-Methyl-D-Aspartate Receptor Complex.

3-アシル-4-ヒドロキシキノリン-2(1H)-オン類 N-メチル-D-アスパラギン酸受容体錯体のグリシン部位に対して作用する全身作用性抗けいれん活性

Author (9)： ROWLEY M (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  LEESON P D (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  STEVENSON G I (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  MOSELEY A M (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  STANSFIELD I (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  SANDERSON I (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  ROBINSON L (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  BAKER R (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  SAYWELL K L (Merck Sharp and Dohme Research Lab., Essex, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 36  Issue： 22  Page： 3386-3396  Publication year： Oct. 29, 1993 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： lactam ,...
Semi thesaurus term： L-701273 ,...

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JST classification (1)： Basic research of antiepileptics and anticonvulsants  (GW03060D)

Substance index (23)： 2-Oxo-6-chloroindoline-3-carboxylic acid methyl ester ,  7-Chloroquinoline-2,4(1H,3H)-dione ,  6-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzothiazine 1,1-dioxide ,  6-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid ethyl ester ,  6-Chloro-3,4-dihydro-3-oxo-2-(methoxycarbonyl)-2H-1,4-benzothiazine 1,1-dioxide ,  7-Chloro-3-(methylsulfonyl)quinoline-2,4(1H,3H)-dione ,  7-Chloro-1,2,3,4-tetrahydro2,4-dioxoquinoline-3-carbonitrile ,  7-Chloro-1,2,3,4-tetrahydro-2,4-dioxoquinoline-3-carboxylic acid ethyl ester ,  L-695902 ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid propyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid allyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid propargyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 3-hydroxybenzyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 3-hydroxyphenethyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 3-(3-hydroxyphenyl)propyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 4-(3-hydroxyphenyl)butyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 2-hydroxyphenethyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 4-hydroxyphenethyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 2-(2-pyridinyl)ethyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 2-(2-thienyl)ethyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 2-(1H-indol-3-yl)ethyl ester ,  1,2-Dihydro-2-oxo-4-hydroxy-7-chloroquinoline-3-carboxylic acid 3-(3-methoxyphenyl)-2-propynyl ester ,  L-701273

Terms in the title (6)： 4-ヒドロキシキノリン ,  N-メチル-D-アスパラギン酸受容体 ,  錯体 ,  グリシン ,  全身 ,  抗けいれん活性