Art

J-GLOBAL ID：200902192545242140   Reference number：99A0120034

Seiective Inhibition of Src Protein Tyrosine Kinase by Analogues of 5-S-Glutathionyl-β-alanyl-L-dopa.

5-S-グルタチオニル-β-アラニル-L-ドーパの類似体によるSrc蛋白チロシンキナーゼの選択的阻害

Author (7)： ZHENG Z-B (Toyama Medical and Pharmaceutical Univ., Toyama, JPN) ,  NAGAI S (Toyama Medical and Pharmaceutical Univ., Toyama, JPN) ,  IWANAMI N (Toyama Medical and Pharmaceutical Univ., Toyama, JPN) ,  KOBAYASHI A (Univ. Tokyo, Tokyo, JPN) ,  HIJIKATA M (Univ. Tokyo, Tokyo, JPN) ,  NATORI S (Univ. Tokyo, Tokyo, JPN) ,  SANKAWA U (Toyama Medical and Pharmaceutical Univ., Toyama, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 46  Issue： 12  Page： 1950-1951  Publication year： Dec. 1998 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *oligopeptide ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Peptides  (CF10080G)

Substance index (12)： 5-S-GAD ,  N-(β-Alanyl)-3-hydroxy-5-[[(S)-2-(L-γ-glutamylamino)-3-(carboxymethylamino)-3-oxopropyl]thio]-D-tyrosine ,  N-(β-Alanyl)-α-methyl-3-hydroxy-5-[[(S)-2-(L-γ-glutamylamino)-3-(carboxymethylamino)-3-oxopropyl]thio]-L-tyrosine ,  N-[3,4-Dihydroxy-5-[[(S)-2-(L-γ-glutamylamino)-3-(carboxymethylamino)-3-oxopropyl]thio]phenethyl]-3-aminopropanamide ,  3-Hydroxy-5-[[(S)-2-(L-γ-glutamylamino)-3-(carboxymethylamino)-3-oxopropyl]thio]-L-tyrosine ,  3-Hydroxy-5-[[(S)-2-(L-γ-glutamylamino)-3-(carboxymethylamino)-3-oxopropyl]thio]-D-tyrosine ,  3-[[(S)-2-(L-γ-Glutamylamino)-3-(carboxymethylamino)-3-oxopropyl]thio]-5-(2-aminoethyl)-1,2-benzenediol ,  2,5-Bis(S-glutathionyl)dopamine ,  N-(β-Alanyl)-3-hydroxy-5-[[(S)-2-amino-2-carboxyethyl]thio]-L-tyrosine ,  N-(β-Alanyl)-3-hydroxy-5-[[(S)-2-amino-2-carboxyethyl]thio]-D-tyrosine ,  3-Hydroxy-5-[[(S)-2-amino-2-carboxyethyl]thio]-L-tyrosine ,  3-Hydroxy-5-[[(S)-2-amino-2-carboxyethyl]thio]-D-tyrosine

Reference (11)：

• 1) Chang C.J., Geahlen R.L., J Nat. Prod., 55, 1529-1560 (1992).
• 2) Kakeya H., Imoto M., Tabata Y., Iwami J., Matsumoto H., Nakamura K., Koyano T., Tadano K., Umezawa K., FEBS Lett., 320, 169-172 (1993).
• 3) Leem J.Y., Nishimura C., Kurata S., Shimada I., Kobayashi A., Natori S., J. Biol. Chem., 271, 13573-13577 (1996).
• 4) Ito S., Prota G., Experientia, 33, 1118-1119 (1977).
• 5) Fujita K., Ito S., Inoue S., Yamamoto Y., Takeuchi J., Shamoto M., Nagatsu T., Cancer Res., 40, 2543-2546 (1980).

Terms in the title (5)： L-ドーパ ,  類似体 ,  SRC ,  蛋白チロシンキナーゼ ,  阻害