Art

J-GLOBAL ID：200902195437937416   Reference number：99A0766459

Preparation of Cysteinol Derivatives by Highly Regioselective Ring Opening of Nonactivated Chiral Aziridines by Thiols.

活性化されていないキラルなアジリジン誘導体を,チオールで高度に位置選択的に開環させることによるシステイノール誘導体の合成

Author (4)： BAE J H (Sogang Univ., Seoul) ,  SHIN S-H (Sogang Univ., Seoul) ,  PARK C S (Sogang Univ., Seoul) ,  LEE W K (Sogang Univ., Seoul)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 55  Issue： 33  Page： 10041-10046  Publication year： Aug. 13, 1999 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： nucleophilic reagent ,...
Semi thesaurus term： rate-determining step

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JST classification (2)： Aliphatic alcohols  (CF03090H) ,  Regiochemistry of organic reaction  (CF02140G)

Substance index (30)： Benzenethiol ,  (2R)-1-[(S)-1-Phenylethyl]aziridine-2-methanol ,  (1R)-1-[(2R)-1-[(S)-1-Phenylethyl]aziridine-2-yl]ethanol ,  (2R,αR)-α-Butyl-1-[(S)-α-methylbenzyl]aziridine-2-methanol ,  (2R,αR)-α-tert-Butyl-1-[(S)-α-methylbenzyl]aziridine-2-methanol ,  (1R)-1-[(2R)-1-[(S)-1-Phenylethyl]aziridine-2-yl]-2-propene-1-ol ,  (1R)-1-[(2R)-1-[(S)-1-Phenylethyl]aziridine-2-yl]-2-heptyne-1-ol ,  (2R,αR)-α-Phenyl-1-[(S)-α-methylbenzyl]aziridine-2-methanol ,  (2R,αR)-α-(2-Methoxyphenyl)-1-[(S)-α-methylbenzyl]aziridine-2-methanol ,  (2R,αR)-α-(3-Methylphenyl)-1-[(S)-α-methylbenzyl]aziridine-2-methanol ,  (2R,αR)-α-(4-Fluorophenyl)-1-[(S)-α-methylbenzyl]aziridine-2-methanol ,  (αR,2R)-α-(1-Naphthyl)-1-[(S)-1-phenylethyl]aziridine-2-methanol ,  (αR,2R)-α-(2-Naphthyl)-1-[(S)-1-phenylethyl]aziridine-2-methanol ,  (2R)-2-[[(S)-1-Phenylethyl]amino]-3-(phenylthio)-1-propanol ,  (1R,2R)-1-Methyl-2-[[(S)-1-phenylethyl]amino]-3-(phenylthio)-1-propanol ,  (2R,3R)-1-(Phenylthio)-2-[[(S)-1-phenylethyl]amino]-3-heptanol ,  (2R,3R)-1-(Phenylthio)-2-[[(S)-1-phenylethyl]amino]-3-pentanol ,  (3R,4R)-4-[[(S)-1-Phenylethyl]amino]-5-(phenylthio)-1-pentene-3-ol ,  (2R,3R)-1-(Phenylthio)-2-[[(S)-1-phenylethyl]amino]-4-nonyne-3-ol ,  (1R,2R)-1-Phenyl-2-[[(S)-1-phenylethyl]amino]-3-(phenylthio)-1-propanol ,  (1R,2R)-1-(2-Methoxyphenyl)-2-[[(S)-1-phenylethyl]amino]-3-(phenylthio)-1-propanol ,  (1R,2R)-1-(3-Methylphenyl)-2-[[(S)-1-phenylethyl]amino]-3-(phenylthio)-1-propanol ,  (1R,2R)-1-(4-Fluorophenyl)-2-[[(S)-1-phenylethyl]amino]-3-(phenylthio)-1-propanol ,  (1R,2R)-1-(1-Naphthyl)-2-[[(S)-1-phenylethyl]amino]-3-(phenylthio)-1-propanol ,  (1R,2R)-1-(2-Naphthyl)-2-[[(S)-1-phenylethyl]amino]-3-(phenylthio)-1-propanol ,  (1R,2R)-1-Phenyl-2-[[(S)-1-phenylethyl]amino]-3-(acetylthio)-1-propanol ,  (1R,2R)-1-Phenyl-2-[[(S)-1-phenylethyl]amino]-3-(4-nitrophenylthio)-1-propanol ,  (1R,2R)-1-Phenyl-2-[[(S)-1-phenylethyl]amino]-3-(4-chlorophenylthio)-1-propanol ,  (1R,2R)-1-Phenyl-2-[[(S)-1-phenylethyl]amino]-3-(benzylthio)-1-propanol ,  (1R,2R)-1-Phenyl-2-[[(S)-1-phenylethyl]amino]-3-(butylthio)-1-propanol

Terms in the title (7)： 活性化 ,  キラル ,  アジリジン誘導体 ,  チオール ,  位置選択 ,  開環 ,  誘導体