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J-GLOBAL ID：200902196078938386   Reference number：99A0192133

Synthetic Inhibitors of DNA Topoisomerase I and II.

DNAトポイソメラーゼI及びIIの合成阻害剤

Author (5)： KATAYAMA H (Niigata Coll. Pharmacy, Niigata, JPN) ,  KAWADA Y (Niigata Coll. Pharmacy, Niigata, JPN) ,  KANEKO K (Niigata Coll. Pharmacy, Niigata, JPN) ,  OSHIYAMA T (Niigata Coll. Pharmacy, Niigata, JPN) ,  TAKATSU N (Niigata Coll. Pharmacy, Niigata, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 47  Issue： 1  Page： 48-53  Publication year： Jan. 1999 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...

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JST classification (3)： Pyrazoles  (CF07082G) ,  Structure-activity relationship of drugs  (GV01050B) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (10)： 1-Methyl-2-phenyl-4H-pyrazolo[1,5-a]indole-1-ium ,  1,2-Dimethyl-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-styryl-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-phenyl-4-benzylidene-4H-pyrazolo[1,5-a]indol-1-ium ,  1-Methyl-2-phenyl-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indol-1-ium ,  1-Methyl-2-phenyl-4-(4-nitrobenzylidene)-4H-pyrazolo[1,5-a]indol-1-ium ,  1,2-Dimethyl-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-styryl-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-phenyl-4-[4-(dimethylamino)phenylimino]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-phenyl-4-[4-(dimethylamino)styryl]-4H-pyrazolo[1,5-a]indole-1-ium

Reference (31)：

• KATAYAMA, H. Chem. Pharm. Bull. 1996, 44, 1276-1278
• RALPH, R. K. Molecular Aspects of Anticancer Drug-DNA Interactions. 1994, 2, 1-95
• PONTMESIL, M. DNA Topoisomerases in Cancer. 1991
• POMMIER, Y. Cancer Chemother. Pharmacol. 1993, 32, 103-108
• D'ARPA, P. Biochim. Biophys. Acta. 1989, 989, 163-177

Terms in the title (2)： DNAトポイソメラーゼI ,  阻害剤