Art

J-GLOBAL ID：200902196520404140   Reference number：01A0681095

Markedly Increased Nasal Blockage by Intranasal Leukotriene D₄ in an Experimental Allergic Rhinitis Model: Contribution of Dilated Mucosal Blood Vessels.

実験的アレルギー性鼻炎モデルにおいて鼻内ロイコトリエンD₄投与は顕著に鼻閉を増強する 拡張した粘膜血管の関与

Author (6)： MIZUTANI N (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  NABE T (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  IMAI A (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  SAKURAI H (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  TAKENAKA H (Osaka Medical Coll., Osaka, JPN) ,  KOHNO S (Kyoto Pharmaceutical Univ., Kyoto, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 86  Issue： 2  Page： 170-182  Publication year： Jun. 01, 2001 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *pollinosis ,...

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JST classification (3)： Basic otorhinolaryngology  (GQ01020F) ,  Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Hormones,cytokines,bioactive peptides in general  (EB08010W)

Substance index (5)： Leukotriene D4 ,  Pranlukast ,  Naphazoline ,  L-NAME ,  AA-861

Reference (28)：

• 1 Shaw RJ, Fitzharris P, Cromwell O, Wardlaw AJ and Kay AB: Allergen-induced release of sulphidopeptide leukotrienes (SRS-A) and LTB₄ in allergic rhinitis. Allergy 40, 1 - 6 (1985)
• 2 Miadonna A, Milazzo N, Gibelli S, Salmaso C, Lorini M and Tedeschi A: Nasal response to a single antigen challenge in patients with allergic rhinitis-inflammatory cell recruitment persists up to 48 hours. Clin Exp Allergy 29, 941 - 949 (1999)
• 3 Knapp HR: Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. N Engl J Med 327, 1745 - 1748 (1990)
• 4 Howarth PH, Harrison K and Lau L: The influence of 5-lipoxygenase inhibition in allergic rhinitis. Int Arch Allergy Appl Immunol 107, 423 - 424 (1995)
• 5 Numata T, Konno A, Yamakoshi T, Hanazawa T, Terada N and Nagata H: Comparative role of peptide leukotrienes and histamine in the development of nasal mucosal swelling in nasal allergy. Ann Otol Rhinol Laryngol 108, 467 - 473 (1999)

Terms in the title (11)： 実験 ,  アレルギー性鼻炎 ,  モデル ,  鼻 ,  ロイコトリエンD4 ,  投与 ,  鼻閉 ,  増強 ,  拡張 ,  粘膜 ,  血管