Art

J-GLOBAL ID：200902197339886385   Reference number：99A1022893

Metabolites of Isopropyl Unoprostone as Potential Ophthalmic Solutions to Reduce Intraocular Pressure in Pigmented Rabbits.

有色ウサギにおける眼圧低下のための強力な眼科薬としてのイソプロピルウノプロストンの代謝

Author (3)： KASHIWAGI K (Yamanashi Medical Univ., Yamanashi, JPN) ,  IIZUKA Y (Yamanashi Medical Univ., Yamanashi, JPN) ,  TSUKAHARA S (Yamanashi Medical Univ., Yamanashi, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 81  Issue： 1  Page： 56-62  Publication year： Sep. 01, 1999 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *prostaglandin ,...
Semi thesaurus term： イソプロピルウノプロストン

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JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of drugs acting on sensory organs  (GW04060K)

Substance index (4)： (5Z,9α,11α)-9,11-Dihydroxy-15-oxoprosta-5-ene-1-oic acid isopropyl ester ,  Prostaglandin FM ,  6-[(1R)-2β-[(Z)-4-Carboxy-2-butenyl]-3β,5β-dihydroxycyclopentane-1α-yl]-4-oxohexanoic acid ,  10-[(1R)-2β-(2-Carboxyethyl)-3β,5β-dihydroxycyclopentane-1α-yl]-8-oxodecanoic acid

Reference (21)：

• 1 Camras CB and Alm A: Initial clinical studies with prostaglandins and their analogues. Sur Ophthalmol 41, S61-8 (1997)
• 2 Alm A: The potential of prostaglandin derivatives in glaucoma therapy. Curr Opin Ophthalmol 4, 44 - 50 (1993)
• 3 Azuma I, Masuda K, Kitazawa Y, Takase M and Yamamura H: Double-masked comparative study of UF-021 and timolol ophthalmic solutions in patients with primary open-angle glaucoma or ocular hypertension. Jpn J Ophthalmol 37, 514 - 525 (1993)
• 4 Goh Y and Kihino J: Pharmacological characterization of prostaglandin-related ocular hypotensive agents. Jpn J Ophthalmol 38, 236 - 245 (1994)
• 5 Ueno R, Yoshida S, Deguchi T, Kato I, Oda T, Hayashi Y and Kuno S: The intraocular pressure lowering effects of UF-021, a novel prostaglandin related compound, in animals. Nippon Ganka Gakkai Zasshi 96, 462 - 468 (1992) (Abstr in English)

Terms in the title (6)： 有色 ,  ウサギ ,  眼圧低下 ,  眼科 ,  イソプロピルウノプロストン ,  代謝