Art

J-GLOBAL ID：200902197381757803   Reference number：96A0185631

Nonpeptide Angiotensin II Receptor Antagonists: Synthesis, Biological Activities, and Structure-Activity Relationships of Imidazole-5-carboxylic Acids Bearing Alkyl, Alkenyl, and Hydroxyalkyl Substituents at the 4-Position and Their Related Compounds.

非ペプチド系アンギオテンシンII受容体遮断薬 4位にアルキル,アルケニルおよびヒドロキシアルキル置換基を有するイミダゾール-5-カルボン酸およびその関連化合物の合成,生物学的活性と構造-活性相関

Author (9)： YANAGISAWA H (Sankyo Co. Ltd., Tokyo, JPN) ,  AMEMIYA Y (Sankyo Co. Ltd., Tokyo, JPN) ,  KANAZAKI T (Sankyo Co. Ltd., Tokyo, JPN) ,  SHIMOJI Y (Sankyo Co. Ltd., Tokyo, JPN) ,  FUJIMOTO K (Sankyo Co. Ltd., Tokyo, JPN) ,  KITAHARA Y (Sankyo Co. Ltd., Tokyo, JPN) ,  SADA T (Sankyo Co. Ltd., Tokyo, JPN) ,  MIZUNO M (Sankyo Co. Ltd., Tokyo, JPN) ,  KOIKE H (Sankyo Co. Ltd., Tokyo, JPN)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 39  Issue： 1  Page： 323-338  Publication year： Jan. 05, 1996 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： carboxylic acid ,...
Semi thesaurus term： アンギオテンシン2受容体 ,...

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JST classification (2)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Imidazoles  (CF07083X)

Substance index (26)： 1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-1H-imidazole-5-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-4-methyl-1H-imidazole-5-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-4-ethyl-1H-imidazole-5-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-4-isopropyl-1H-imidazole-5-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-4-(1-methylethenyl)-1H-imidazole-5-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-4-hydroxymethyl-1H-imidazole-5-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-4-(1-hydroxyethyl)-1H-imidazole-5-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-4-(1-hydroxy-1-methylethyl)-1H-imidazole-5-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-4-(1-hydroxy-1-methylpropyl)-1H-imidazole-5-carboxylic acid ,  4′-[[2-Propyl-4-hydroxymethyl-5-ethoxycarbonyl-1H-imidazol-1-yl]methyl]-1,1′-biphenyl-2-carboxylic acid ,  4′-[[2-Propyl-4-(1-hydroxy-1-methylethyl)-5-ethoxycarbonyl-1H-imidazol-1-yl]methyl]-1,1′-biphenyl-2-carboxylic acid ,  4′-[[2-Propyl-4-carboxy-5-hydroxymethyl-1H-imidazol-1-yl]methyl]-1,1′-biphenyl-2-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-1H-imidazole-4-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-propyl-1H-imidazole-4,5-dicarboxylic acid ,  4′-[[2-Propyl-4,5-bis(hydroxymethyl)-1H-imidazol-1-yl]methyl]-1,1′-biphenyl-2-carboxylic acid ,  1-[(2′-Carboxy-1,1′-biphenyl-4-yl)methyl]-2-ethyl-4-(1-hydroxy-1-methylethyl)-1H-imidazole-5-carboxylic acid ,  1-[[2′-(1H-Tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-2-propyl-1H-imidazole-5-carboxylic acid ,  1-[[2′-(1H-Tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-2-propyl-4-methyl-1H-imidazole-5-carboxylic acid ,  DMP-811 ,  1-[[2′-(1H-Tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-2-propyl-4-isopropyl-1H-imidazole-5-carboxylic acid ,  1-[[2′-(1H-Tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-2-propyl-4-(1-methylethenyl)-1H-imidazole-5-carboxylic acid ,  1-[[2′-(1H-Tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-2-propyl-4-hydroxymethyl-1H-imidazole-5-carboxylic acid ,  1-[[2′-(1H-Tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-2-propyl-4-(1-hydroxyethyl)-1H-imidazole-5-carboxylic acid ,  Olmesartan ,  1-[[2′-(1H-Tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-2-propyl-1H-imidazole-4-carboxylic acid ,  1-[[2′-(1H-Tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-2-propyl-1H-imidazole-4,5-dicarboxylic acid

Terms in the title (10)： ペプチド ,  アンギオテンシンII受容体 ,  遮断薬 ,  ヒドロキシアルキル ,  置換基 ,  イミダゾール ,  カルボン酸 ,  関連化合物 ,  生物学的活性 ,  構造-活性相関