Art

J-GLOBAL ID：200902197820218183   Reference number：98A0113243

Chronotoxicity of Methotrexate in Mice and Its Relation to Circadian Rhythm of DNA Synthesis and Pharmacokinetics.

マウスにおけるメトトレキセートの時間毒性及びDNA合成と薬物動態のサーカディアンリズムとの関係

Author (6)： OHDO S (Kyushu Univ., Fukuoka, JPN) ,  INOUE K (Kyushu Univ., Fukuoka, JPN) ,  YUKAWA E (Kyushu Univ., Fukuoka, JPN) ,  HIGUCHI S (Kyushu Univ., Fukuoka, JPN) ,  NAKANO S (Oita Medical Univ., Oita, JPN) ,  OGAWA N (Ehime Univ., School of Medicine, Ehime, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 75  Issue： 3  Page： 283-290  Publication year： Nov. 1997 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： diurnal rhythm ,...
Semi thesaurus term： AUC ,...

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Methotrexate

Reference (28)：

• 1) Lévi F, Horvath C, Mechkouri M, Roulon A, Bailleul F, Lemaigre G, Reinberg A and Mathe G: Circadian time depend ence of murine tolerance for the alkylating agent peptichemio. Eur J Cancer Clin Oncol 23, 487-497 (1987)
• 2) Boughattas NA, Lévi F, Fournier C, Lemaigre G, Roulon A, Hecquet B, Mathe G and Reinberg A: Circadian rhythm in toxicities and tissue uptake of 1,2-diaminocyclohexane(trans-1) oxalatoplatinum(II) in mice. Cancer Res 49, 3362-3368 (1989)
• 3) Bjarnason GA and Hrushesky WJM: Cancer chronotherapy. In Circadian Cancer Therapy, Edited by Hrushesky WJM, pp 241-263, CRC Press, Boca Raton, Ann Arbor, London and Tokyo (1994)
• 4) Smaaland R, Lote K, Sothern RB and Laerum OD: DNA synthesis and ploidy in non-Hodgkin''s lymphomas demonstrate intrapatient variation depending on circadian stage of cell sampling. Cancer Res 53, 3129-3138 (1993)
• 5) Buchi KN, Moore JG, Hrushesky WJM, Sothern RB and Rubin NH: Circadian rhythm of cellular proliferation in the human rectal mucosa. Gastroenterology 101, 410-415 (1991)

Terms in the title (6)： マウス ,  メトトレキセート ,  毒性 ,  DNA合成 ,  薬物動態 ,  サーカディアンリズム