O<sup>6</sup>-Methylguanine-DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives.

OKAMOTO R; TAKANO H; OKAMURA T; PARK J-S; TANIMOTO K; SEKIKAWA T; YAMAMOTO W; SPARREBOOM A; NISHIYAMA M

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J-GLOBAL ID：200902197987027371 Reference number：02A0169412

O⁶-Methylguanine-DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives.

カンプトテシン誘導体に対する耐性の決定因子としてのO⁶-メチルグアニン-DNAメチルトランスフェラーゼ(MGMT)

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Volume： 93 Issue： 1 Page： 93-102 Publication year： Jan. 31, 2002
JST Material Number： F0633A ISSN： 0910-5050 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Chemistry,biochemistry and pathology of tumors(=neoplasms) , Enzyme in general

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Reference (23)：

POMMIER, Y. Cellular determinants of sensitivity and resistance to camptothecins. Camptothecins: New Anticancer Agents. 1995, 123-138
TAKAHASHI, T. The role of glucuronidation in 7-ethyl-10-hydroxy-camptothecin resistance in vitro. Jpn. J. Cancer Res. 1997, 88, 1211-1217
SLICHENMYER, W. J. The current status of camptothecin analogues as anti-tumor agents. J. Natl. Cancer Inst. 1993, 85, 271-291
MITSUI, I. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn. J. Cancer Res. 1995, 86, 776-782
JOTO, N. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int. J. Cancer. 1997, 72, 680-686

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O6-Methylguanine-DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives.

O⁶-Methylguanine-DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives.