Art

J-GLOBAL ID：200902198080932347   Reference number：00A0182055

Structure-Activity Relationship of Hydroxamate-Based Inhibitors on Membrane-Bound Fas Ligand and TNF-α Processing.

膜結合性FasリガンドとTNFαのプロセッシングに対する,ヒドロキサム酸塩をベースにした阻害剤の構造活性相関

Author (9)： YAMAMOTO M (Kanebo, Ltd., Osaka, JPN) ,  HIRAYAMA R (Kanebo, Ltd., Osaka, JPN) ,  NARUSE K (Kanebo, Ltd., Osaka, JPN) ,  YOSHINO K (Kanebo, Ltd., Osaka, JPN) ,  SHIMADA A (Kanebo Ltd., Kanagawa, JPN) ,  INOUE S (Kanebo Ltd., Kanagawa, JPN) ,  KAYAGAKI N (Juntendo Univ. School of Medicine, Tokyo, JPN) ,  YAGITA H (Juntendo Univ. School of Medicine, Tokyo, JPN) ,  IKEDA S (Kanebo, Ltd., Osaka, JPN)
Material： Drug Design and Discovery  (Drug Des Discov)
Volume： 16  Issue： 2  Page： 119-130  Publication year： Aug. 1999 
JST Material Number： T0150A  ISSN： 1055-9612  CODEN： DDDIEV  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *TNF alpha ,...
Semi thesaurus term： *cytotoxin

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JST classification (1)： Structure-activity relationship of drugs  (GV01050B)

Substance index (14)： (2R)-N-[(S)-1-Phenyl-2-(methylamino)-2-oxoethyl]-N′-hydroxy-2-isobutylbutanediamide ,  KB-R-7785 ,  (S)-2-[(R)-2-[(S)-1-(Hydroxycarbamoyl)ethyl]-4-methylpentanoylamino]-N-methyl-2-(4-methoxyphenyl)acetamide ,  N^α-[(R)-2-[(S)-(Hydroxycarbamoyl)[3,4-dihydroisoquinoline-2(1H)-yl]methyl]-4-methylpentanoyl]-N-methyl-L-phenylglycinamide ,  (2R)-N-[(S)-1-Cyclohexyl-2-(methylamino)-2-oxoethyl]-N′-hydroxy-2-isobutylbutanediamide ,  (S)-2-[(R)-2-(Hydroxycarbamoylmethyl)-4-methylpentanoylamino]-N-methyl-2-(2-naphthyl)acetamide ,  (S)-2-[(R)-2-(Hydroxycarbamoylmethyl)-4-methylpentanoylamino]-N-methyl-2-[4-(carboxymethoxy)phenyl]acetamide ,  N^α-[(R)-2-[(S)-1-(Hydroxycarbamoyl)ethyl]-4-methylpentanoyl]-N-methyl-3-(1-naphthyl)-L-alaninamide ,  KB-8301 ,  N^α-[(R)-2-(Hydroxycarbamoylmethyl)-4-phenylbutyryl]-N-methyl-L-phenylglycinamide ,  N^α-[(R)-2-(Hydroxycarbamoylmethyl)-5-phenylpentanoyl]-N-methyl-L-phenylglycinamide ,  N^α-[(R)-2-(Hydroxycarbamoylmethyl)-5-phenylpentanoyl]-N-methyl-3-(1-naphthyl)alaninamide ,  N^α-[(R)-2-(Hydroxycarbamoylmethyl)undecanoyl]-N-methyl-L-phenylglycinamide ,  N^α-[(R)-2-[(S)-1-(Hydroxycarbamoyl)ethyl]-3-methylbutyryl]-N-methyl-L-phenylalaninamide

Terms in the title (8)： 膜結合 ,  Fasリガンド ,  TNFα ,  プロセッシング ,  ヒドロキサム酸 ,  塩 ,  阻害剤 ,  構造活性相関