Art

J-GLOBAL ID：200902200311389751   Reference number：09A0286468

Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells

アディポネクチンは血管平滑筋細胞においてAktではなく細胞外シグナル制御キナーゼ1/2活性化の抑制にてインシュリン様成長因子1誘発性細胞遊走を阻害する

Author (10)： MOTOBAYASHI Yuki (Univ. Tokushima Graduate School, Tokushima, JPN) ,  IZAWA-ISHIZAWA Yuki (Univ. Tokushima Graduate School, Tokushima, JPN) ,  ISHIZAWA Keisuke (Univ. Tokushima Graduate School, Tokushima, JPN) ,  ORINO Sakiko (Univ. Tokushima Graduate School, Tokushima, JPN) ,  YAMAGUCHI Kunihisa (Univ. Tokushima Graduate School, Tokushima, JPN) ,  KAWAZOE Kazuyoshi (Tokushima Univ. Hospital, Tokushima, JPN) ,  HAMANO Shuichi (Univ. Tokushima Graduate School, Tokushima, JPN) ,  TSUCHIYA Koichiro (Univ. Tokushima Graduate School, Tokushima, JPN) ,  TOMITA Shuhei (Univ. Tokushima Graduate School, Tokushima, JPN) ,  TAMAKI Toshiaki (Univ. Tokushima Graduate School, Tokushima, JPN)
Material： Hypertension Research  (Hypertens Res)
Volume： 32  Issue： 3  Page： 188-193  Publication year： Mar. 2009 
JST Material Number： Y0303A  ISSN： 0916-9636  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Vasculature  (EJ04030O)

Substance index (1)： AICAR

Reference (28)：

• KADOWAKI, T. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006, 116, 1784-1792
• WAKI, H. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem. 2003, 278, 40352-40363
• KUMADA, M. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol. 2003, 23, 85-89
• PISCHON, T. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 2004, 291, 1730-1737
• KUBOTA, N. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem. 2002, 277, 25863-25866

Terms in the title (8)： アディポネクチン ,  血管平滑筋細胞 ,  AKT ,  細胞外シグナル制御キナーゼ1 ,  活性化 ,  インシュリン様成長因子1 ,  細胞遊走 ,  阻害