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J-GLOBAL ID:200902200384753800   Reference number:07A1115366

呼吸器感染症に対するスタチンの役割 スタチンの多面的効果(プレイオトロピック効果)

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Volume: 55  Issue: 11  Page: 1261-1265  Publication year: Nov. 15, 2007 
JST Material Number: Z0660A  ISSN: 0452-3458  Document type: Article
Article type: 解説  Country of issue: Japan (JPN)  Language: JAPANESE (JA)
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Drug therapy(=pharmacotherapy)for respiratory system diseases  ,  Basic research of drugs acting on lipid metabolism  ,  Clinical application of drugs acting on lipid metabolism 
Reference (24):
  • Schlienger RG, Fedson DS, Jick SS, et al: Statins and the risk of pneumonia: a population-based, nested case-control study. Pharmacotherapy 27: 325-332, 2007〔英国General Practice Research Databaseからスタチンand/orフィブラート服用患者, 服用していない患者に分けてnested case control studyを行った. スタチン服用中の患者では有意に肺炎死亡リスクが軽減した.〕
  • Mortensen EM, Restrepo MI, Anzueto A, et al: The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia. Respir Res 6: 82-88, 2005〔retrospective cohort studyであるが, 787名の市中肺炎で入院した患者をスタチン服用患者, 非服用患者に分けて検討したところ, スタチン服用患者では非服用患者に比べて, 30日間の死亡率が有意に低下した.〕
  • van de Garde EM, Hak E, Souverein PC, et al: Statin treatment and reduced risk of pneumonia in patients with diabetes. Thorax 61: 957-961, 2006〔英国General Practice Research Databaseで1987年6月から2001年1月までに1型および2型糖尿病と診断された患者, 肺炎と初回診断された患者でcase-control studyを行ったところ, スタチン服用にて有意に肺炎リスクが軽減した.〕
  • Majumdar SR, McAlister FA, Eurich DT, et al: Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study. BMJ 333: 999-1001, 2006
  • Rosenson RS, Tangney CC, Casey LC: Inhibition of proinflammatory cytokine production by pravastatin. Lancet 353: 983-984, 1999
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