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J-GLOBAL ID：200902201525693527   Reference number：09A0243501

Establishment of a Mouse Model to Assess Brain Neurotransmitter Level and Learning Performance Simultaneously Following Toxic Chemical Exposure: Using in vivo Microdialysis and Schedule-Controlled Operant Behavior

インビボマイクロダイアリシスとオペラント行動を用いて有害化学物質曝露後の神経伝達物質と学習行動を同時に評価するための動物モデルの確立

Author (6)： WIN-SHWE Tin-Tin (National Inst. Environmental Studies, Ibaraki, JPN) ,  HOJO Rieko (National Inst. Environmental Studies, Ibaraki, JPN) ,  MITSUSHIMA Dai (Yokohama City Univ. Graduate School of Medicine, Yokohama, JPN) ,  NAKAJIMA Daisuke (National Inst. Environmental Studies, Ibaraki, JPN) ,  YAMAMOTO Shoji (National Inst. Environmental Studies, Ibaraki, JPN) ,  FUJIMAKI Hidekazu (National Inst. Environmental Studies, Ibaraki, JPN)
Material： Journal of UOEH (University of Occupational and Environmental Health)  (Journal of University of Occupational and Environmental Health)
Volume： 31  Issue： 1  Page： 1-11  Publication year： Mar. 01, 2009 
JST Material Number： Z0840A  ISSN： 0387-821X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Microdialysis ,...

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JST classification (1)： Occupational health,industorial accidents  (GB05000S)

Substance index (2)： Glutamic acid ,  Toluene

Reference (20)：

• Arlien-Soborg P, Hansen L, Ladefoged O & Simonsen L (1992): Report on a conference on organic solvents and the nervous system. Neurotoxicol Teratol 14: 81-82
• Chouaniere D, Wild P, Fontana JM et al (2002): Neurobehavioral disturbances arising from occupational toluene exposure. Am J Ind Med 41: 77-88
• Lee YL, Pai MC, Chen JH & Guo YL (2003): Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure. Occup Med 53: 479-482
• Yu IT, Lee NL, Zhang XH, Chen WQ, Lam YT & Wong TW (2004): Occupational exposure to mixtures of organic solvents increases the risk of neurological symptoms among printing workers in Hong Kong. J Occup Environ Med 46: 323-330
• von Euler G, Ogren SO, Li XM, Fuxe K & Gustafsson JA (1993): Persistent effects of subchronic toluene exposure on spatial learning and memory, dopamine-mediated locomotor activity and dopamine D2 agonist binding in the rat. Toxicology 77: 223-232

Terms in the title (8)： オペラント行動 ,  有害化学物質 ,  曝露 ,  神経伝達物質 ,  学習行動 ,  評価 ,  動物 ,  モデル