Art

J-GLOBAL ID：200902203032475477   Reference number：04A0337537

Orally Active CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Activity of 1-Benzothiepine 1,1-Dioxide and 1-Benzazepine Derivatives Containing a Tertiary Amine Moiety

抗HIV-1剤としての経口活性CCR5きっ抗薬: 第三アミン部分を含む1-ベンゾチエピン1,1-ジオキシド及び1-ベンゾアゼピン誘導体の合成及び生物活性

Author (9)： SETO M (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  ARAMAKI Y (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  OKAWA T (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  MIYAMOTO N (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  AIKAWA K (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  KANZAKI N (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  NIWA S (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  IIZAWA Y (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  BABA M (Kagoshima Univ., Kagoshima, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 52  Issue： 5  Page： 577-590  Publication year： May. 01, 2004 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...

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JST classification (2)： Seven-membered heterocyclic compounds  (CF07110I) ,  Synthesis of drugs  (GV01030F)

Substance index (17)： 7-Bromo-2,3,4,5-tetrahydro-1-benzothiepin-5-one ,  N-Cbz-GABA ,  1-Ethyl-7-bromo-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid tert-butyl ester ,  1-Propyl-7-bromo-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid tert-butyl ester ,  2-(Tosylamino)-5-bromobenzoic acid methyl ester ,  7-Bromo-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid methyl ester ,  4-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]anilinocarbonyl]-7-(4-methylphenyl)-2,3-dihydro-1-benzothiepin 1,1-dioxide ,  N-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]phenyl]-1-methyl-7-(4-methylphenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide ,  4-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]anilinocarbonyl]-7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepin 1,1-dioxide ,  4-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]anilinocarbonyl]-7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepin 1,1-dioxide ,  4-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]anilinocarbonyl]-7-(4-morpholinophenyl)-2,3-dihydro-1-benzothiepin 1,1-dioxide ,  4-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]anilinocarbonyl]-7-[4-(2-ethoxyethoxy)phenyl]-2,3-dihydro-1-benzothiepin 1,1-dioxide ,  4-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]anilinocarbonyl]-7-[4-(2-propoxyethoxy)phenyl]-2,3-dihydro-1-benzothiepin 1,1-dioxide ,  4-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]anilinocarbonyl]-7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-benzothiepin 1,1-dioxide ,  N-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]phenyl]-1-propyl-7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxamide ,  N-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]phenyl]-1-isobutyl-7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxamide ,  N-[4-[[Methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]phenyl]-1-(1-methyl-1H-pyrazole-4-ylmethyl)-7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Terms in the title (8)： HIV-1 ,  活性 ,  CCR5 ,  きっ抗薬 ,  第三アミン ,  ベンゾチエピン ,  ベンゾアゼピン誘導体 ,  生物活性