Art

J-GLOBAL ID：200902203261764857   Reference number：08A0242288

Synthesis of “Trioxaquantel” Derivatives as Potential New Antischistosomal Drugs

新規抗住血吸虫薬としての可能性を持つ“トリオキサカンテル”の合成

Author (7)： LAURENT Sophie A.-L. (Lab. de Chimie de Coordination, CNRS, Toulouse, FRA) ,  BOISSIER Jerome (UPVD, Perpignan, FRA) ,  COSLEDAN Frederic (Palumed, Labege, FRA) ,  GORNITZKA Heinz (Univ. Paul Sabatier, Toulouse, FRA) ,  ROBERT Anne (Lab. de Chimie de Coordination, CNRS, Toulouse, FRA) ,  MEUNIER Bernard (Lab. de Chimie de Coordination, CNRS, Toulouse, FRA) ,  MEUNIER Bernard (Palumed, Labege, FRA)
Material： European Journal of Organic Chemistry  (Eur J Org Chem)
Volume： 2008  Issue： 5  Page： 895-913  Publication year： Feb. 2008 
JST Material Number： W1026A  ISSN： 1434-193X  CODEN： EJOCFK  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： Schistosomiasis ,  antimalarial drug ,  *anthelmintic ,  Schistosoma mansoni ,  Heme ,  crystallization ,  molecular design ,  chemical synthesis ,  complementation ,  *oxygen heterocyclic compound ,  *nitrogen heterocyclic compound ,  Mus musculus ,  crystal structure ,  toxicity test ,  in vitro experiment ,  space structure ,  alicyclic compound ,  lactone ,  bridged compound ,  lactam ,  polynuclear aromatic compound ,  haemozoin ,  50% inhibitory concentration ,  invertebrate ,  Myomorpha
Semi thesaurus term： IC50 ,  Schistosoma mansoni

JST classification (3)： Basic research of antiprotozoan drugs and anthelmintics  (GW17080G) ,  Synthesis of drugs  (GV01030F) ,  Other 6-membered rings with three or more hetero atoms  (CF07108D)

Substance index (6)： Artemisinin ,  Praziquantel ,  2-(3,3-Dimethyl-1,2,5-trioxaspiro[5.5]undecane-9-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-4-one ,  2-(3,3-Dimethyl-1,2,5-trioxaspiro[5.5]undecane-9-ylcarbonyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-4-one ,  2-(3,3,9-Trimethyl-1,2,5-trioxaspiro[5.5]undecane-9-ylcarbonyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-4-one ,  2-(3,3-Dimethyl-9-fluoro-1,2,5-trioxaspiro[5.5]undecane-9-ylcarbonyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-4-one

Terms in the title (2)： 抗住血吸虫薬 ,  可能性