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J-GLOBAL ID：200902203499771983   Reference number：08A0070590

INHIBITORY OLIGODEOXYNUCLEOTIDE IMPROVES GLOMERULONEPHRITIS AND PROLONGS SURVIVAL IN MRL-lpr/lpr MICE

阻害性オリゴデオキシヌクレオチドは重症自己免疫疾患モデルマウスにおける生存を延長し糸球体腎炎を改善する

Author (9)： HOSHI Namiko (Fukushima Medical Univ., Fukushima, JPN) ,  WATANABE Hiroshi (Fukushima Medical Univ., Fukushima, JPN) ,  KOBAYASHI Hiroko (Fukushima Medical Univ., Fukushima, JPN) ,  SEKINE Hideharu (Fukushima Medical Univ., Fukushima, JPN) ,  HOSHI Nobuo (Fukushima Medical Univ., Fukushima, JPN) ,  SUGINO Takashi (Fukushima Medical Univ., Fukushima, JPN) ,  SUZUKI Toshimitsu (Fukushima Medical Univ., Fukushima, JPN) ,  SATO Yukio (Fukushima Medical Univ., Fukushima, JPN) ,  OHIRA Hiromasa (Fukushima Medical Univ., Fukushima, JPN)
Material： Fukushima Journal of Medical Science  (Fukushima J Med Sci)
Volume： 53  Issue： 2  Page： 70-84  Publication year： Dec. 2007 
JST Material Number： F0632A  ISSN： 0016-2590  CODEN： FJMSA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *autoimmune disease ,...
Semi thesaurus term： lupus nephritis ,...

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JST classification (3)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Basic medicine on urogenital system  (GM01020T) ,  Biological function  (EB04020F)

Reference (41)：

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• LATZ, E. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol. 2004, 5, 190-198
• AHMAD-NEJAD, P. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol. 2002, 32, 1958-1968
• LEIFER, CA. TLR9 is localized in the endoplasmic reticulum prior to stimulation. J Immunol. 2004, 173, 1179-1183
• LEADBETTER, EA. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 2002, 11, 603-607

Terms in the title (7)： 阻害 ,  オリゴデオキシヌクレオチド ,  重症 ,  自己免疫疾患 ,  モデルマウス ,  生存 ,  糸球体腎炎