Art

J-GLOBAL ID：200902203737333329   Reference number：09A0831100

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

マウス膵臓におけるPax4の異所性発現は前駆細胞をα細胞に転換後β細胞に転換する

Author (22)： COLLOMBAT Patrick (Dep. of Molecular Cell Biology, Max-Planck Inst. for Biophysical Chemistry, Am Fassberg, D-37077 Goettingen, DEU) ,  COLLOMBAT Patrick (Beta Cell Biology Consortium, 2213 Garland Avenue, 9465 MRB IV, Nashville, TN 37323-0494, USA) ,  COLLOMBAT Patrick (JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, BEL) ,  XU Xiaobo (Diabetes Res. Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BEL) ,  RAVASSARD Philippe (JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, BEL) ,  RAVASSARD Philippe (Biotechnology and Biotherapy Lab., Centre de Rech. de l’Institut du Cerveau et de la Moelle, CNRS UMR 7225, INSERM ...) ,  SOSA-PINEDA Beatriz (Dep. of Genetics/Tumor Cell Biology, St. Jude Children’s Res. Hospital, 262 Danny Thomas Place, Memphis, TN ...) ,  DUSSAUD Sebastien (Biotechnology and Biotherapy Lab., Centre de Rech. de l’Institut du Cerveau et de la Moelle, CNRS UMR 7225, INSERM ...) ,  DUSSAUD Sebastien (Centre d’Experimentation Fonctionnelle, Pitie Salpetriere Medical Fac., Univ. Pierre et Marie Curie, FR-75013 Paris, FRA) ,  BILLESTRUP Nils (Dep. of Translational Diabetology Res. Inst., Hagedorn Niels Steensensvej 6, DK-2820 Gentofte, DNK) ,  MADSEN Ole D. (Beta Cell Biology Consortium, 2213 Garland Avenue, 9465 MRB IV, Nashville, TN 37323-0494, USA) ,  MADSEN Ole D. (JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, BEL) ,  MADSEN Ole D. (Dep. of Developmental Biology Res. Inst., Hagedorn Niels Steensensvej 6, DK-2820 Gentofte, DNK) ,  SERUP Palle (Beta Cell Biology Consortium, 2213 Garland Avenue, 9465 MRB IV, Nashville, TN 37323-0494, USA) ,  SERUP Palle (JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, BEL) ,  SERUP Palle (Dep. of Developmental Biology Res. Inst., Hagedorn Niels Steensensvej 6, DK-2820 Gentofte, DNK) ,  HEIMBERG Harry (Beta Cell Biology Consortium, 2213 Garland Avenue, 9465 MRB IV, Nashville, TN 37323-0494, USA) ,  HEIMBERG Harry (JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, BEL) ,  HEIMBERG Harry (Diabetes Res. Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BEL) ,  MANSOURI Ahmed (Dep. of Molecular Cell Biology, Max-Planck Inst. for Biophysical Chemistry, Am Fassberg, D-37077 Goettingen, DEU) ,  MANSOURI Ahmed (Beta Cell Biology Consortium, 2213 Garland Avenue, 9465 MRB IV, Nashville, TN 37323-0494, USA) ,  MANSOURI Ahmed (Dep. of Clinical Neurophysiology, Univ. of Goettingen, Robert-Koch Strasse 40, D-37075 Goettingen, DEU)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 138  Issue： 3  Page： 449-462  Publication year： Aug. 07, 2009 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： DNA binding protein ,  *transcription factor ,  gene expression ,  *Langerhans islet ,  cell ,  *internal secretion ,  glucagon ,  cell differentiation ,  transgenic mouse ,  embryogenesis ,  RT-PCR ,  morphogenesis ,  sugar tolerance ,  age specificity ,  cell proliferation ,  adult(development) ,  diabetes mellitus ,  experimental disease ,  intraperitoneal administration ,  immunostaining ,  confocal microscope ,  nitrosamine ,  hexosamine ,  urea compound ,  insulin
Semi thesaurus term： insulin ,  *Pax4 ,  pancreatic alpha cell ,  pancreatic beta cell ,  *insulin secretion ,  committed stem cell ,  Age dependency ,  real time RT-PCR method ,  Streptozotocin-Induced Diabetes ,  immunohistological stain

JST classification (4)： Cell physiology in general  (EF02010S) ,  Pancreas  (EJ06050Y) ,  Physiology and anatomy of endocrine system  (EJ08000J) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (1)： Streptozocin

Terms in the title (8)： マウス ,  膵臓 ,  Pax4 ,  異所性発現 ,  前駆細胞 ,  細胞 ,  転換 ,  β細胞