Art

J-GLOBAL ID：200902204419427973   Reference number：08A0285947

Threshold-like Dose-response Relationships in a Modified Linear-no-threshold Model: Application of Experimental Data and Risk Evaluation

改良線形-閾値なしモデルにおける閾値-様用量応答関係 実験データの適用およびリスク評価

Author (1)： WATANABE Masahiko (School of Pharmacy, Shujitsu Univ.)
Material： Genes and Environment  (Genes Environ)
Volume： 30  Issue： 1  Page： 17-24 (J-STAGE)  Publication year： 2008 
JST Material Number： X0839A  ISSN： 1880-7046  CODEN： GEENGP  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： parameter ,...
Semi thesaurus term： *dosage dependence ,...

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JST classification (3)： Basic oncology in general  (GE02010R) ,  Toxicology in general  (GZ01000K) ,  Research methods in biological sciences in general  (EA03010K)

Substance index (1)： MNNG

Reference (12)：

• 1 U.S. Environmental Protection Agency. Guidelines for carcinogen risk assessment; 2005 Mar. Report EPA/630/ P-03/001F.
• 2 Hengstler JG, Bogdanffy MS, Bolt HM, Oesch F. Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate. Annu Rev Pharmacol Toxicol. 2003; 43: 485-520.
• 3 Sofuni T, Nohmi T, Ohta T, Hayashi M. Genotoxicity: is a threshold concept applicable to evaluate the mutagenic activity of DNA-targeting substances!? Environ Mutagen Res. 2005; 27: 61-73 (in Japanese).
• 4 Snow ET, Foote RS, Mitra S. Base-pairing properties of O⁶-methyguanine in template DNA during in vitro DNA replication. J Biol Chem. 1984; 259: 8095-100.
• 5 Loechler EL, Green CL, Essigmann JM. In vivo mutagenesis by O⁶-methylguanine built into a unique site in a viral genome. Proc Natl Acad Sci USA. 1984; 81: 6271-5.

Terms in the title (6)： 線形 ,  閾値 ,  モデル ,  用量 ,  実験データ ,  リスク評価