Art

J-GLOBAL ID：200902206168886135   Reference number：03A0271732

Inhibition and Facilitation by Pimobendan, a Calcium Sensitizer, of Catecholamine Secretion From Bovine Adrenal Chromaffin Cells

ウシ副腎クロム親和性細胞からのカテコールアミン分泌に対するカルシウム増感剤ピモベンダンによる阻害と促進

Author (3)： KUWASHIMA H (Nippon Dental Univ. School of Dentistry at Niigata, Niigata, JPN) ,  MATSUMURA C (Nippon Dental Univ. School of Dentistry at Niigata, Niigata, JPN) ,  KIMURA T (Nippon Dental Univ. School of Dentistry at Niigata, Niigata, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 91  Issue： 3  Page： 211-218  Publication year： Mar. 01, 2003 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： cattle ,...
Semi thesaurus term： カルシウム増感剤

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JST classification (1)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Pimobendan

Reference (45)：

• 1 Sata M, Sugiura S, Yamashita H, Aoyagi T, Momomura S and Serizawa T: Pimobendan directly sensitizes reconstituted thin filament to slide on cardiac myosin. Eur J Pharmacol 290, 55 – 59 (1995)
• 2 Fujino K, Sperelakis N and Solaro RJ: Sensitization of dog and guinea pig heart myofilaments to Ca²⁺ activation and the inotropic effect of pimobendan: comparison with milrinone. Circ Res 63, 911 – 922 (1988)
• 3 Jaquet K and Heilmeyer LM Jr: Influence of association and of positive inotropic drugs on calcium binding to cardiac troponin C. Biochem Biophys Res Commun 145, 1390 – 1396 (1987)
• 4 Ruegg JC, Pfitzer G, Eubler D and Zeugner C: Effect on contractility of skinned fibers from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methy l-3(2H)-pyridazinone. Arzneimittelforschung 34, 1736 – 1738 (1984)
• 5 Böhm M, Morano I, Pieske B, Ruegg JC, Wankerl M, Zimmermann R and Erdmann E: Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium. Circ Res 68, 689 – 701 (1991)

Terms in the title (10)： ウシ ,  副腎 ,  クロム親和性細胞 ,  カテコールアミン ,  分泌 ,  カルシウム ,  増感剤 ,  ピモベンダン ,  阻害 ,  促進