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J-GLOBAL ID:200902206684934448   Reference number:04A0381473

KATP Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-negative Form of Human Insulin Receptor Have Glucose Intolerance but not Diabetes

KATPチャンネルノックアウトマウスとヒトインシュリン受容体の優勢負型を発現したトランスジェニックマウスの雑種はグルコース不耐性だが,糖尿病ではない
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Volume: 51  Issue:Page: 133-144  Publication year: Apr. 2004 
JST Material Number: F0625A  ISSN: 0918-8959  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: ENGLISH (EN)
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Metabolic diseases,nutritional diseases in general. 
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Reference (20):
  • 1. Seino S, Iwanaga T, Nagashima K, Miki T (2000) Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice. Diabetes 49: 311-318.
  • 2. Gromada J, Holst JJ, Rorsman P (1998) Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. Pflugers Arch 435: 583-594.
  • 3. Ding WG, Gromada J (1997) Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptide. Diabetes 46: 615-621.
  • 4. Ahren B, Taborsky GJ Jr, Porte D Jr (1986) Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion. Diabetologia 29: 827-836.
  • 5. Jamen F, Persson K, Bertrand G, Rodriguez-Henche N, Puech R, Bockaert J, Ahren B, Brabet P (2000) PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. J Clin Invest 105: 1307-1315.
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