Art

J-GLOBAL ID：200902207056433380   Reference number：09A0818132

A Candidate Anti-Prion Disease Agent, 2,2’-Biquinoline, Decreases Expression of Prion Protein and mRNA in Prion-Infected Cells

抗プリオン病薬剤候補の2,2′-ビキノリンはプリオン感染細胞におけるプリオン蛋白質とmRNA発現の減少させる

Author (4)： FUKUUCHI Tomoko (Fac. of Pharmaceutical Sciences, Hiroshima International Univ.) ,  OKUDA Katsuhiro (Fac. of Pharmaceutical Sciences, Hiroshima International Univ.) ,  YOSHIHARA Shin'ichi (Fac. of Pharmaceutical Sciences, Hiroshima International Univ.) ,  OHTA Shigeru (Graduate School of Biomedical Sciences, Hiroshima Univ.)
Material： Journal of Health Science  (J Health Sci)
Volume： 55  Issue： 4  Page： 586-592 (J-STAGE)  Publication year： 2009 
JST Material Number： S0030A  ISSN： 1344-9702  CODEN： JHSCFD  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： prion ,...
Semi thesaurus term： Wasting Disease, Chronic ,...

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JST classification (1)： Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y)

Substance index (1)： 2,2'-Biquinoline

Reference (29)：

• 1) Collinge, J. (2001) Prion diseases of humans and animals: their causes and molecular basis. Annu. Rev. Neurosci., 24, 519-550.
• 2) Giese, A. and Kretzschmar, H. A. (2001) Prion-induced neuronal damage—the mechanisms of neuronal destruction in the subacute spongiform encephalopathies. Curr. Top. Microbiol. Immunol., 253, 203-217.
• 3) Brown, D. R. (2004) Metallic prions. Biochem. Soc. Symp., 193-202.
• 4) Prusiner, S. B. (1982) Novel proteinaceous infectious particles cause scrapie. Science, 216, 136-144.
• 5) Stahl, N., Borchelt, D. R., Hsiao, K. and Prusiner, S. B. (1987) Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell, 51, 229-240.

Terms in the title (6)： プリオン病 ,  薬剤 ,  プリオン感染 ,  細胞 ,  プリオン蛋白質 ,  mRNA発現