Art

J-GLOBAL ID：200902207163227482   Reference number：09A0004567

Organocatalytic activity of 4-hydroxy-prolinamide alcohol with different noncovalent coordination sites in asymmetric Michael and direct aldol reactions

不斉Michaelおよび直接アルドール反応における異なる非共有結合性配位サイトを有する4-ヒドロキシプロリンアミドアルコールの有機触媒活性

Author (8)： OKUYAMA Yuko (Dep. of Organic Reaction Chemistry, Tohoku Pharmaceutical Univ., 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JPN) ,  NAKANO Hiroto (Dep. of Organic Reaction Chemistry, Tohoku Pharmaceutical Univ., 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JPN) ,  WATANABE Yuki (Dep. of Organic Reaction Chemistry, Tohoku Pharmaceutical Univ., 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JPN) ,  MAKABE Mika (Dep. of Organic Reaction Chemistry, Tohoku Pharmaceutical Univ., 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JPN) ,  TAKESHITA Mitsuhiro (Dep. of Organic Reaction Chemistry, Tohoku Pharmaceutical Univ., 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JPN) ,  UWAI Koji (Dep. of Organic Reaction Chemistry, Tohoku Pharmaceutical Univ., 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JPN) ,  KABUTO Chizuko (Res. and Analytical Center for Giant Molecules, Graduate School of Sci., Tohoku Univ., 6-3 Aoba, Aramaki, Aoba-ku ...) ,  KWON Eunsang (Res. and Analytical Center for Giant Molecules, Graduate School of Sci., Tohoku Univ., 6-3 Aoba, Aramaki, Aoba-ku ...)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 50  Issue： 2  Page： 193-197  Publication year： Jan. 14, 2009 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： amino acid ,  *nitrogen heterocyclic compound ,  carboxamide ,  alcohol ,  asymmetric reaction ,  asymmetric catalyst ,  catalyst ,  organic compound ,  Michael reaction ,  aldol reaction ,  catalytic activity ,  transition state ,  density functional method ,  aliphatic aldehyde ,  aromatic aldehyde ,  aliphatic ketone ,  alicyclic ketone
Semi thesaurus term： amino acids ,  organocatalyst

JST classification (2)： Pyrroles  (CF07076L) ,  Stereochemistry of organic reaction  (CF02130V)

Substance index (28)： L-Prolinamide ,  N-[(S)-α-(α-Hydroxybenzhydryl)phenethyl]-4β-hydroxy-L-prolinamide ,  N-[(S)-1,1,2-Triphenyl-2-hydroxyethyl]-4β-hydroxy-L-prolinamide ,  N-[(S)-1-(α-Hydroxybenzhydryl)-3-methylbutyl]-4β-hydroxy-L-prolinamide ,  1-(Benzyloxycarbonyl)-4β-hydroxy-L-proline ,  1-(Benzyloxycarbonyl)-4α-hydroxy-L-proline ,  (S)-1,1,3-Triphenyl-2-amino-1-propanol ,  (S)-1,1,2-Triphenyl-2-aminoethanol ,  (-)-α-(1-Amino-3-methylbutyl)benzhydrol ,  (R)-1,1,3-Triphenyl-2-amino-1-propanol ,  Butyraldehyde ,  β-Nitrostyrene ,  (2R,3S)-2-Ethyl-3-phenyl-4-nitrobutanal ,  Benzaldehyde ,  Acetone ,  (R)-1-Hydroxy-1-phenyl-3-butanone ,  4-Nitrobenzaldehyde ,  3-Methoxybenzaldehyde ,  4-Piperidinecarbaldehyde ,  Cyclohexanone ,  Tetrahydro-4H-pyran-4-one ,  Tetrahydro-4H-thiopyran-4-one ,  2α-[(R)-α-Hydroxybenzyl]cyclohexanone ,  2α-[(R)-α-Hydroxy-4-nitrobenzyl]cyclohexanone ,  2α-[(R)-α-Hydroxy-3-methoxybenzyl]cyclohexanone ,  3β-[(R)-α-Hydroxybenzyl]tetrahydro-4H-pyran-4-one ,  3β-[(R)-α-Hydroxybenzyl]tetrahydro-4H-thiopyran-4-one ,  2α-[(R)-Hydroxy(4-pyridinyl)methyl]cyclohexanone

Terms in the title (6)： アルドール反応 ,  非共有結合 ,  4-ヒドロキシプロリン ,  アミド ,  アルコール ,  触媒活性