Art

J-GLOBAL ID：200902207639327871   Reference number：07A0265338

Aplyronine A, a potent antitumor macrolide of marine origin, and the congeners aplyronines B and C: isolation, structures, and bioactivities

海洋生物起源の強力な抗腫よう薬マクロリド,アプリロニンA,及び同類物質のアプリロニンB及びC 単離,構造,並びに生物活性

Author (9)： OJIKA Makoto (Graduate School of Bioagricultural Sciences, Nagoya Univ., Chikusa-ku, Nagoya 464-8601, JPN) ,  KIGOSHI Hideo (Dep. of Chemistry, Univ. of Tsukuba, Tsukuba, Ibaraki 305-8751, JPN) ,  YOSHIDA Yoshifumi (Graduate School of Sci., Nagoya Univ., Chikusa-ku, Nagoya 464-8602, JPN) ,  ISHIGAKI Takeshi (Graduate School of Sci., Nagoya Univ., Chikusa-ku, Nagoya 464-8602, JPN) ,  NISIWAKI Masanori (Graduate School of Sci., Nagoya Univ., Chikusa-ku, Nagoya 464-8602, JPN) ,  TSUKADA Itaru (Graduate School of Sci., Nagoya Univ., Chikusa-ku, Nagoya 464-8602, JPN) ,  ARAKAWA Masayuki (Pharmaceutical Res. Laboratories, Res. and Dev. Group, Nippon Kayaku Co. Ltd, Kita-ku, Tokyo 115-8588, JPN) ,  EKIMOTO Hisao (Pharmaceutical Res. Laboratories, Res. and Dev. Group, Nippon Kayaku Co. Ltd, Kita-ku, Tokyo 115-8588, JPN) ,  YAMADA Kiyoyuki (Graduate School of Sci., Nagoya Univ., Chikusa-ku, Nagoya 464-8602, JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 63  Issue： 15  Page： 3138-3167  Publication year： Apr. 09, 2007 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： biological activity ,...
Semi thesaurus term： congener

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JST classification (3)： Other natural substances of biological origin  (CF10090R) ,  Animal biochemistry  (EJ01050P) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (20)： (S)-2-Amino-1-propanol ,  Aplyronine A ,  Aplyronine B ,  Aplyronine C ,  4-Bromobenzoic acid 2-(dimethylamino)-3-methoxypropyl ester ,  4-Bromobenzoic acid 2-(dimethylamino)propyl ester ,  (3R,4R,5R,6R,9S,10R)-1,10-Bis(4-bromophenylcarbamoyloxy)-3,5-diacetoxy-4,6-dimethyl-9-methoxyundecane ,  (3R,4R,5R,6R,9S,10S)-1,10-Bis(4-bromophenylcarbamoyloxy)-3,5-diacetoxy-4,6-dimethyl-9-methoxyundecane ,  (2R,4R)-1,6-Bis(4-bromophenylcarbamoyloxy)-2-methoxy-4-methylhexane ,  (3R,4R,5S,6R,9S,10S,11R,12S)-1,4:1,6-Diepoxy-3,5,9,11-tetramethyl-10,12-diacetoxy-14-(4-bromophenylcarbamoyloxy)tetradecane ,  (3R,4R,5R,6R,9S,10R)-1,10-Bis(4-bromophenylcarbamoyloxy)-3,5-(isopropylidenedioxy)-4,6-dimethyl-9-methoxyundecane ,  (3R,4R,5R,6R,9S,10S,11R,12S)-1,4:1,6-Diepoxy-3,5,9,11-tetramethyl-10,12-(isopropylidenedioxy)-14-(4-bromophenylcarbamoyloxy)tetradecane ,  (4R)-2,2-Dimethyl-3-(tert-butoxycarbonyl)oxazolidine-4α-methanol ,  4-Bromobenzoic acid (2R)-2-(dimethylamino)-3-methoxypropyl ester ,  4-Bromobenzoic acid (2S)-2-(dimethylamino)propyl ester ,  (3S,4S,5S,6S,9R,10S)-1,10-Bis(4-bromobenzoyloxy)-3,5-diacetoxy-4,6-dimethyl-9-methoxyundecane ,  (3S,4S,5S,6S,9R,10R)-1,10-Bis(4-bromobenzoyloxy)-3,5-diacetoxy-4,6-dimethyl-9-methoxyundecane ,  (2S,4R)-1,6-Bis(4-bromophenylcarbamoyloxy)-2-methoxy-4-methylhexane ,  (2S,3R,4S,5S)-1-Pivaloyl-2,4-(isopropylidenedioxy)-3,5-dimethyl-6-(tert-butyldiphenylsilyloxy)hexane ,  (3S,4S,5R,6S,9R,10R,11S,12R)-1,4:1,6-Diepoxy-3,5,9,11-tetramethyl-10,12-diacetoxy-14-(4-bromophenylcarbamoyloxy)tetradecane

Terms in the title (9)： 海洋 ,  生物起源 ,  抗腫よう薬 ,  マクロリド ,  アプリロニンA ,  同類物質 ,  アプリロニンB ,  単離 ,  生物活性