Art

J-GLOBAL ID：200902207854552002   Reference number：07A1047251

Effects of Pioglitazone on Increases in Visceral Fat Accumulation and Oxidative Stress in Spontaneously Hypertensive Hyperlipidemic Rats Fed a High-Fat Diet and Sucrose Solution

高脂肪食および蔗糖液を給餌した自然発症高血圧高脂血症ラットにおける内臓脂肪蓄積および酸化ストレスの増加に及ぼすピオグリタゾンの効果

Author (6)： SAIKI Ryo (Dep. of Pharmacology, Showa Univ. School of Medicine, JPN) ,  OKAZAKI Masako (Dep. of Pharmacology, Showa Univ. School of Medicine, JPN) ,  IWAI Shinichi (Dep. of Pharmacology, Showa Univ. School of Medicine, JPN) ,  KUMAI Toshio (Dep. of Pharmacology, St. Marianna Univ. School of Medicine, JPN) ,  KOBAYASHI Shinichi (Dep. of Pharmacology, St. Marianna Univ. School of Medicine, JPN) ,  OGUCHI Katsuji (Dep. of Pharmacology, Showa Univ. School of Medicine, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 105  Issue： 2  Page： 157-167 (J-STAGE)  Publication year： 2007 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *hypoglycemic drug ,...
Semi thesaurus term： syndrome X(obesity) ,...

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JST classification (1)： Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (3)： Pioglitazone ,  L-NAME ,  Sucrose

Reference (51)：

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• 3 Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601–2610.
• 4 Rask-Madsen C, King GL. Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab. 2007;3:46–56.
• 5 Alexander CM. The coming of age of the metabolic syndrome. Diabetes Care. 2003;26:3180–3181.

Terms in the title (10)： 高脂肪食 ,  蔗糖 ,  給餌 ,  自然発症 ,  血圧 ,  高脂血症 ,  ラット ,  内臓脂肪蓄積 ,  酸化ストレス ,  ピオグリタゾン