Art

J-GLOBAL ID：200902208579967317   Reference number：04A0135226

Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

プラスミノーゲン活性化因子阻害剤1(PAI-1)の阻害剤としてのピペラジンに基づく誘導体の合成と生物的評価

Author (9)： YE B (Berlex Biosci., CA, USA) ,  CHOU Y-L (Berlex Biosci., CA, USA) ,  KARANJAWALA R (Berlex Biosci., CA, USA) ,  LEE W (Berlex Biosci., CA, USA) ,  LU S-F (Berlex Biosci., CA, USA) ,  SHAW K J (Berlex Biosci., CA, USA) ,  JONES S (Berlex Biosci., CA, USA) ,  LENTZ D (Berlex Biosci., CA, USA) ,  LIANG A (Berlex Biosci., CA, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 14  Issue： 3  Page： 761-765  Publication year： Feb. 09, 2004 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...
Semi thesaurus term： PAI1

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JST classification (3)： Pyrazines  (CF07104N) ,  Basic research of drugs acting on blood and body fluid  (GW14010M) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (10)： 1-[2-(Trifluoromethyl)-4-nitro-5-[4-[3-(trifluoromethyl)phenyl]piperazino]phenyl]piperidine-4-carboxylic acid ,  N-[2-(Trifluoromethyl)-4-nitro-5-[4-[3-(trifluoromethyl)phenyl]piperazino]phenyl]-β-alanine ,  2-(Trifluoromethyl)-4-nitro-5-[4-[3-(trifluoromethyl)phenyl]piperazino]phenylaminomethylphosphonic acid ,  2-[2-[3-(Trifluoromethyl)-4-[4-[3-(trifluoromethyl)phenyl]piperazino]phenylaminomethyl]-6-methoxyphenoxy]-5-nitrobenzoic acid ,  2-[2-[3-(Trifluoromethyl)-4-[4-[3-(trifluoromethyl)phenyl]piperazino]phenylaminomethyl]-6-methoxyphenoxy]-3-nitro-5-chlorobenzoic acid ,  2-[2-[3-(Trifluoromethyl)-4-[4-[3-(trifluoromethyl)phenyl]piperazino]phenylaminomethyl]-3-fluorophenoxy]-5-bromobenzoic acid ,  2-[2-[3-(Trifluoromethyl)-4-[4-[3-(trifluoromethyl)phenyl]piperazino]phenylaminomethyl]-4-nitrophenoxy]benzoic acid ,  6-[2-[3-(Trifluoromethyl)-4-[4-[3-(trifluoromethyl)phenyl]piperazino]phenylaminomethyl]-6-methoxyphenoxy]pyridine-3-carboxylic acid ,  1-[2-[3-(Trifluoromethyl)-4-[4-[3-(trifluoromethyl)phenyl]piperazino]phenylaminomethyl]-3-fluorophenyl]piperidine-4-carboxylic acid ,  1-[2-[3-(Trifluoromethyl)-4-[4-[3-(trifluoromethyl)phenyl]piperazino]phenylaminomethyl]-3-fluoro-6-nitrophenyl]piperidine-4-carboxylic acid

Terms in the title (7)： プラスミノーゲン活性化因子阻害剤1 ,  PAI-1 ,  阻害剤 ,  ピペラジン ,  誘導体 ,  生物 ,  評価