Art

J-GLOBAL ID：200902209033512650   Reference number：09A0301401

遺伝子多型情報による生物学的製剤の事前効果判定は関節リウマチ患者にminimum cost,maximum outcomeの治療を提供し,医療経済効果を飛躍的に高める!

Author (4)： FUNAHASHI KEIKO (松原メイフラワー病院) ,  MATSUBARA TSUKASA (松原メイフラワー病院) ,  NAKAHARA KUNIHIKO (ヒュービットジェノミクス) ,  TORIYAMA SAYUMI (ヒュービットジェノミクス)
Material： 医学と薬学  (Japanese Journal of Medicine and Pharmaceutical Science)
Volume： 61  Issue： 3  Page： 337-343  Publication year： Mar. 25, 2009 
JST Material Number： F0597B  ISSN： 0389-3898  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： genetic polymorphism ,...
Semi thesaurus term： *rheumatoid arthritis ,...

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JST classification (4)： Clinical application of anti-inflammatory drugs  (GW15020E) ,  Clinical application of immunotherapeutic agents and blood preparations  (GW22020O) ,  Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D) ,  Treatment for immunologic diseases,allergic diseases.  (GD04030Y)

Substance index (1)： Embrel

Reference (9)：

• Matsubara T et al: Algorithm using Genomewide SNP Analysis for Prediction of Responder and Non-responder, and Adverse Events of Infliximab-or Etanercept-treated RA Patients. ACR/ARHP Annual Scientific Meeting, Presentation Number 970, 2008.
• 舟橋恵子 他: 抗TNFα製剤投薬関節リウマチ患者 (RA) に対するゲノム薬理学的探索--効果と副作用に対する検討--. 日本リウマチ学会総会・学術集会抄録集, p257, 2008.
• van der Biji et al: Inflixmab and methotrexate as induction therapy in patients with early rheumatoid arthritis. ArthritisRheum 56: 2129-2134, 2007.
• Quinn MA et al: Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial. Arthritis Rheum 52: 27-35, 2005.
• Goekoop-Ruiterman YP et al: Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial. Arthritis Rheum 52: 3381-3390, 2005.

Terms in the title (8)： 遺伝子多型 ,  生物学的製剤 ,  効果判定 ,  関節リウマチ ,  患者 ,  治療 ,  医療 ,  経済効果