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J-GLOBAL ID：200902209392482928   Reference number：08A0740506

Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A₂ and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88

Toxoplasma gondii由来熱ショック蛋白質70はサイトゾルホスホリパーゼA2の活性化を通して致死性アナフィラキシー反応を誘導し,Toll様受容体4/MyD88経由で血小板活性化因子を誘導する

Author (7)： FANG Hao (Chiba Univ., Chiba, JPN) ,  MUN Hye-Seong (Chiba Univ., Chiba, JPN) ,  KIKUMURA Akitoshi (Chiba Univ., Chiba, JPN) ,  SAYAMA Yusuke (Chiba Univ., Chiba, JPN) ,  NOROSE Kazumi (Chiba Univ., Chiba, JPN) ,  YANO Akihiko (Chiba Univ., Chiba, JPN) ,  AOSAI Fumie (Chiba Univ., Chiba, JPN)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 52  Issue： 7  Page： 366-374  Publication year： Jul. 2008 
JST Material Number： W1957A  ISSN： 0385-5600  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *Toxoplasma gondii ,...
Semi thesaurus term： cellular signal transduction

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JST classification (2)： Infectious immunity  (ED03030P) ,  Physiology and pathogenicity of microbial infection  (EG03053T)

Reference (55)：

• MUN, H. S. Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice. Cell Stress & Chaperones. 2000, 5, 328-335
• CHEN, M. Anti-HSP70 autoantibody formation by B-1 cells in Toxoplasma gondii-infected mice. Infect Immun. 2000, 68, 4893-4899
• CHEN, M. The role of anti-HSP70 autoantibody-forming VH1-JH1 B-1 cells in Toxoplasma gondii-infected mice. Int Immunol. 2003, 15, 39-47
• MUN, H. S. A novel B-2 suppressor cell regulating susceptibility/resistance of mice to Toxoplasma gondii infection. Microbiol Immunol. 2005, 49, 853-858
• AHMED, A. K. Roles of Toxoplasma gondii-derived heat shock protein 70 in host defense against T. gondii infection. Microbiol Immunol. 2004, 48, 911-915

Terms in the title (10)： Toxoplasma ,  熱ショック蛋白質70 ,  サイトゾルホスホリパーゼA2 ,  活性化 ,  致死性 ,  アナフィラキシー反応 ,  誘導 ,  Toll様受容体4 ,  MyD88 ,  血小板活性化因子