Art

J-GLOBAL ID：200902209591346740   Reference number：09A0081465

Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion

内在性GLP-1分泌を促進する新規糖尿病薬としての結腸標的化DHAとEPAの有用性

Author (4)： MORISHITA Mariko (Hoshi Univ., Tokyo, JPN) ,  TANAKA Tomohiro (Hoshi Univ., Tokyo, JPN) ,  SHIDA Takayuki (Hoshi Univ., Tokyo, JPN) ,  TAKAYAMA Kozo (Hoshi Univ., Tokyo, JPN)
Material： Journal of Controlled Release  (J Control Release)
Volume： 132  Issue： 2  Page： 99-104  Publication year： Dec. 08, 2008 
JST Material Number： C0308D  ISSN： 0168-3659  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *peptide hormone ,...
Semi thesaurus term： *GLP-1 ,...

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JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (3)： Eicosapentaenoic Acid ,  Docosahexaenoic acid ,  Linolic acid

Reference (19)：

• M.B. Wheeler, M. Lu, J.S. Dillon, X.H. Leng, C. Chen, A.E. Boyd III, Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C, Endocrinology 133 (1) (1993) 57-62.
• F. Preitner, M. Ibberson, I. Franklin, C. Binnert, M. Pende, A. Gjinovci, T. Hansotia, D.J. Drucker, C. Wollheim, R. Burcelin, B. Thorens, Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors, J. Clin. Invest. 113 (4) (2004) 635-645.
• J.F. Gautier, S. Fetita, E. Sobngwi, C. Salaün-Martin, Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes, Diabetes Metab. 31 (3 I) (2005) 233-242.
• T. Vilsboll, T. Krarup, J. Sonne, S. Madsbad, A. Volund, A.G. Juul, J.J. Holst, Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus, J. Clin. Endocrinol. Metab. 88 (6) (2003) 2706-2713.
• J.J. Holst, Glucagonlike peptide 1: a newly discovered gastrointestinal hormone, Gastroenterology 107 (6) (1994) 1848-1855.

Terms in the title (9)： GLP-1 ,  分泌 ,  促進 ,  糖尿病薬 ,  結腸 ,  標的化 ,  DHA ,  EPA ,  有用性