Art

J-GLOBAL ID：200902210611586279   Reference number：05A0685143

Effect of CYP2D6*10 on the Pharmacokinetics of R- and S-Carvedilol in Healthy Japanese Volunteers

健常日本人ボランティアにおけるR-及びS-カルベジロールの薬物動力学に及ぼすCYP2D6^*10の作用

Author (9)： HONDA Mutsuko (Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Univ.) ,  NOZAWA Takashi (Second Dep. of Internal Medicine, Fac. of Medicine, Toyama Medical and Pharmaceutical Univ.) ,  IGARASHI Norio (Second Dep. of Internal Medicine, Fac. of Medicine, Toyama Medical and Pharmaceutical Univ.) ,  INOUE Hiroshi (Second Dep. of Internal Medicine, Fac. of Medicine, Toyama Medical and Pharmaceutical Univ.) ,  ARAKAWA Rie (Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Univ.) ,  OGURA Yumi (Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Univ.) ,  OKABE Hiromi (Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Univ.) ,  TAGUCHI Masato (Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Univ.) ,  HASHIMOTO Yukiya (Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 28  Issue： 8  Page： 1476-1479 (J-STAGE)  Publication year： 2005 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： CYP2D6 ,...

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JST classification (3)： Basic biopharmacy  (GY01021U) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Enzyme physiology  (EJ02020P)

Substance index (3)： (R)-Carvedilol ,  (S)-Carvedilol ,  Carvedilol

Reference (24)：

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• 2) Eggertsen R., Sivertsson R., Andren L., Hansson L., J. Cardiovasc. Pharmacol., 10 (Suppl. 11), S97—100 (1987).
• 3) Nagele H., Bohlmann M., Eck U., Petersen B., Rodiger W., Eur. J. Heart. Fail., 2, 71—79 (2000).
• 4) Nahrendorf W., Rading A., Steinig G., van der Does R., Schlote A., J. Cardiovasc. Pharmacol., 19 (Suppl. 1), S114—116 (1992).
• 5) Neugebauer G., Akpan W., von Mollendorff E., Neubert P., Reiff K., J. Cardiovasc. Pharmacol., 10 (Suppl. 11), S85—88 (1987).

Terms in the title (4)： 日本人 ,  ボランティア ,  カルベジロール ,  薬物動力学