Art

J-GLOBAL ID：200902210837349857   Reference number：05A0551971

Local Application of Simvastatin to Rat lincisor Socket: Carrier-dependent Effect on Bone Augmentation

ラット切歯腔へのシンバスタチンの局所適用 骨形成促進に及ぼす担体依存的効果

Author (6)： SATO Daisuke (Tokyo Medical and Dental Univ.) ,  NISHIMURA Kenichi (Tokyo Medical and Dental Univ.) ,  ISHIOKA Tatsunari (Tokyo Medical and Dental Univ.) ,  KONDO Hisatomo (Tokyo Medical and Dental Univ.) ,  KURODA Shinji (Tokyo Medical and Dental Univ.) ,  KASUGAI Shohei (Tokyo Medical and Dental Univ.)
Material： Journal of Oral Tissue Engineering  (J Oral Tissue Eng)
Volume： 2  Issue： 2  Page： 81-85  Publication year： Mar. 30, 2005 
JST Material Number： L5068A  ISSN： 1348-9623  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *osteogenic factor ,...
Semi thesaurus term： bone morphogenetic protein

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JST classification (2)： Basic dentistry(= odontology)  (GT01020O) ,  Basic research of drugs acting on lipid metabolism  (GW13040M)

Substance index (1)： Simvastatin

Reference (5)：

• 1)Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G. Stimulation of bone formation in vitro and in rodents by statins. Science 1999; 286: 1946-1949.
• 2)Sato D. Socket Healing after Rat Mandibular Incisor Extraction. Kokubyo Gakkai Zasshi. The Journal of Stomatological Society, Japan. 2005; 72 (in Japanese) in press
• 3)Thylin MR, McConnell JC, Schmid MJ, Reckling RR, Ojha J, Bhattacharyya I, Marx DB, Reinhardt JO. Effects of simvastatin gels on murine calvarial bone. J Periodontalogy, 2002; 73:1141-1148.
• 4)Wong RWK, Rabie ABM. Statin collagen grafts used to repair defects in the parietal bone of rabbits. British J Oral Maxillofacial Surgery, 2003; 41:244-248.
• 5)Ayukawa Y, Okuyama A, Koyano K. Simvastatin promotes osteogenesis around titanium implants. Histological and histomorphometrical study in rats. Clinical Oral Implant Research, 2004; 15:346-350.

Terms in the title (6)： ラット ,  切歯 ,  シンバスタチン ,  局所適用 ,  骨形成促進 ,  担体