Art

J-GLOBAL ID：200902210942775152   Reference number：09A0524203

Analysis of Interindividual Variability and Race Difference in the Pharmacokinetics of β-blocker for Personalized Medicine in Heart Failure Patients

心不全の個別薬物療法を目的としたβ遮断薬の体内動態変動機構と人種差に関する研究

Author (1)： TAGUCHI MASATO (富山大 大学院医学薬学研究部 医薬品安全性学研究室)
Material： 医療薬学  (Japanese Journal of Pharmaceutical Health Care and Sciences)
Volume： 35  Issue： 5  Page： 301-315  Publication year： May. 10, 2009 
JST Material Number： Y0888A  ISSN： 1346-342X  CODEN： IYRAA3  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *cardiac insufficiency ,...
Semi thesaurus term： CYP2D6

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JST classification (1)： Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M)

Substance index (3)： Metoprolol ,  Carvedilol ,  Bisoprolol

Reference (33)：

• 1)F.Waagstein,A.Hjalmarson,E.Varnauskas,I.Wallentin,Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy,Br.Heart J .,37,1022-1036 (1975).
• 2)F.Waagstein,M.R.Bristow,K.Swedberg,F.Camerini,M.B.Fowler,M.A.Silver,E.M.Gilbert,M.R.Johnson,F.G.Goss,A.Hjalmarson,Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy.Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group,Lancet ,342,1441- 1446 (1993).
• 3)M.Yano,K.Ono,T.Ohkusa,M.Suetsugu,M.Kohno,T.Hisaoka,S.Kobayashi,Y.Hisamatsu,T.Yamamoto,M.Kohno,N.Noguchi,S.Takasawa,H.Okamoto,M.Matsuzaki,Altered stoichiometry of FKBP 12.6 versus ryanodine receptor as a cause of abnormal Ca²⁺ leak through ryanodine receptor in heart failure,Circulation ,102,2131-2136 (2000).
• 4)S.O.Marx,S.Reiken,Y.Hisamatsu,T.Jayaraman,D.Burkhoff,N.Rosemblit,A.R.Marks,PKA phosphorylation dissociates FKBP 12.6 from the calcium release channel (ryanodine receptor) : defective regulation in failing hearts,Cell ,101,365-376 (2000).
• 5)S.Reiken,X.H.Wehrens,J.A.Vest,A.Barbone,S.Klotz,D.Mancini,D.Burkhoff,A.R.Marks,Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure,Circulation ,107,2459-2466 (2003).

Terms in the title (6)： 心不全 ,  薬物療法 ,  β遮断薬 ,  体内動態 ,  人種差 ,  研究