Art

J-GLOBAL ID：200902211310771344   Reference number：08A0823252

Amyloid-β protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory

アルツハイマー病患者の脳から直接単離されたアミロイドβタンパク質二量体はシナプス可塑性と記憶を損なう

Author (14)： SHANKAR Ganesh M (Harvard Medical School, Massachusetts, USA) ,  LI Shaomin (Harvard Medical School, Massachusetts, USA) ,  MEHTA Tapan H (Harvard Medical School, Massachusetts, USA) ,  GARCIA-MUNOZ Amaya (Univ. Coll. Dublin, Dublin, IRL) ,  SHEPARDSON Nina E (Harvard Medical School, Massachusetts, USA) ,  SMITH Imelda (Univ. Coll. Dublin, Dublin, IRL) ,  BRETT Franceca M (Beaumont Hospital and Royal Coll. of Surgeons Ireland, Dublin, IRL) ,  FARRELL Michael A (Beaumont Hospital and Royal Coll. of Surgeons Ireland, Dublin, IRL) ,  ROWAN Michael J (Trinity Coll., Dublin, IRL) ,  LEMERE Cynthia A (Harvard Medical School, Massachusetts, USA) ,  REGAN Ciaran M (Univ. Coll. Dublin, Dublin, IRL) ,  WALSH Dominic M (Univ. Coll. Dublin, Dublin, IRL) ,  SABATINI Bernardo L (Harvard Medical School, Massachusetts, USA) ,  SELKOE Dennis J (Harvard Medical School, Massachusetts, USA)
Material： Nature Medicine  (Nat Med)
Volume： 14  Issue： 8  Page： 837-842  Publication year： Aug. 2008 
JST Material Number： W0636A  ISSN： 1078-8956  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Alzheimer Disease ,  patient ,  *amyloid beta-protein ,  *dimer ,  *neurophysiology ,  *memory (psychology) ,  Public Health ,  experimental disease ,  *cerebral cortex ,  *Eumetopias jubata ,  Rodentia ,  glutamate receptor ,  neurotransmitter ,  *NMDA receptor ,  solubilization ,  synapse ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  dicarboxylic acid ,  secondary amine ,  *Neuronal Plasticity ,  *synapse plasticity ,  Receptors, Metabotropic Glutamate ,  *Amyloid ,  *glycoprotein ,  *animal protein ,  *cortex ,  *telencephalon ,  Mammalia
Semi thesaurus term： Receptors, Metabotropic Glutamate

JST classification (2)： Basic neurology  (GN01020W) ,  Biological function  (EB03040U)

Substance index (1)： NMDA

Terms in the title (7)： アルツハイマー病 ,  患者 ,  脳 ,  単離 ,  アミロイドβタンパク質 ,  二量体 ,  シナプス可塑性