Art

J-GLOBAL ID：200902211637793805   Reference number：04A0543162

Effect of Experimental Acute Renal and Hepatic Failure on Absorption of Tacrolimus in Rat Small Intestine

ラット小腸におけるタクロリムスの吸収に与える実験的急性腎不全と肝不全の影響

Author (7)： TAMURA S (Fujisawa Pharmaceutical Co., LTD., Osaka, JPN) ,  OHIKE A (Fujisawa Pharmaceutical Co., LTD., Osaka, JPN) ,  TOKUNAGA Y (Fujisawa Pharmaceutical Co., LTD., Osaka, JPN) ,  IBUKI R (Fujisawa Pharmaceutical Co., LTD., Osaka, JPN) ,  AMIDON G L (Univ. Michigan, MI, USA) ,  SEZAKI H (Setsunan Univ., Osaka, JPN) ,  YAMASHITA S (Setsunan Univ., Osaka, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 19  Issue： 3  Page： 190-197  Publication year： Jun. 30, 2004 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *immunosuppressant ,...
Semi thesaurus term： *acute kidney failure ,...

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JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (2)： Tacrolimus ,  Ketoconazole

Reference (29)：

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• 2) Todo, S., Fung, J., Starzl, T. E., Tzakis, A., Demetris, A. J., Kormos, R., Jain, A., Alessiani, M., Takaya, S. and Shapiro, R.: Liver, kidney and thoracic organ transplantation under FK506. Ann. Surg., 212: 295-305 (1990).
• 3) Jusko, W. J., Piekoszewski, W., Klintmalm, G. B., Shaefer, M. S., Hebert, M. F., Piergies, A. A., Lee, C. C., Schechter, P. and Mekki, Q. A.: Pharmacokinetics of tacrolimus in liver transplant patients. Clin. Pharmacol. Ther., 57: 281-290 (1995).
• 4) Venkataramanan, R., Swaminathan, A., Prasad, T., Jain, A., Zuckerman, S., Warty, V., Mcmichael, J., Lever, J., Burckart, G. and Starzl, T. E.: Clinical pharmacokinetics of tacrolimus. Clin. Pharmacokinet., 29: 404-430 (1995).
• 5) Tamura, S., Tokunaga, Y., Ibuki, R., Amidon, G. L. Sezaki, H. and Yamashita, S.: The site-specific transport and metabolism of tacrolimus in rat small intestine. J. Pharmacol. Exp. Ther., 306: 310-316 (2003).

Terms in the title (6)： ラット ,  小腸 ,  タクロリムス ,  実験 ,  急性腎不全 ,  肝不全