Art

J-GLOBAL ID：200902211899913380   Reference number：05A0602733

Prediction of Theophylline Clearance in CCl₄-treated Rats Using in vivo CYP1A2 and CYP3A2 Contents Assessed with the PKCYP Test

薬物動態学的CYP診断方法(PKCYP test)を用いたin vivoでのCYP1A2及びCYP3A2量測定による四塩化炭素処理ラットにおけるテオフィリンクリアランスの予測

Author (6)： KOSE Noriko (Kyoritsu Univ. Pharmacy, Tokyo, JPN) ,  YAMAMOTO Keiko (Kyoritsu Univ. Pharmacy, Tokyo, JPN) ,  SAI Yoshimichi (Kyoritsu Univ. Pharmacy, Tokyo, JPN) ,  ISAWA Minae (Kyoritsu Univ. Pharmacy, Tokyo, JPN) ,  SUWA Toshio (Kyoritsu Univ. Pharmacy, Tokyo, JPN) ,  NAKASHIMA Emi (Kyoritsu Univ. Pharmacy, Tokyo, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 20  Issue： 3  Page： 168-176  Publication year： Jun. 27, 2005 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： in vivo experiment ,...
Semi thesaurus term： benzodiazepine tranquilizer ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=05A0602733&from=J-GLOBAL&jstjournalNo=X0758A") }}

JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (2)： Carbon Tetrachloride ,  Midazolam

Reference (20)：

• 1) Rane, A., Wilkinsonand, G. R. and Shand, D. G.: Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance. J. Pharmacol. Exp. Ther., 200: 420-424 (1977).
• 2) Wilkinson, G. R.: Clearance approaches in pharmacology. Pharmacol. Rev., 39: 1-47 (1987).
• 3) Iwatsubo, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C. E., Tyson, C. A., Yokoi, T., Kamataki, T. and Sugiyama, Y.: Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes. J. Pharmacol. Exp. Ther., 282: 909-919 (1997).
• 4) Matsunaga, N., Hattori, K., Iizasa, H., Fukuhara, M., Takanaka, A. and Nakashima, E.: A simplified diagnostic approach for estimating in vivo hepatic drug clearance; Its preliminary application for the drug caffeine, using CYP1A probe in a rat model. Jpn. J. Hosp. Pharm., 26: 492-504 (2000).
• 5) Matsunaga, N., Hattori, K., Iizasa, H., Kizu, J., Takanaka, A. and Nakashima, E.: Application of the PKCYP-test in cases of altered CYP1A2 for multiple CYP systems in rat models of disease. Biol. Pharm. Bull., 24: 1037-1043 (2001).

Terms in the title (8)： 薬物動態学 ,  CYP ,  診断 ,  CYP1A2 ,  CYP3A2 ,  四塩化炭素 ,  ラット ,  予測